WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H596583
CAS#: 87770-13-6
Description: L 647318 is a Hydroxymethylglutaryl-CoA Reductase Inhibitor.
Hodoodo Cat#: H596583
Name: L 647318
CAS#: 87770-13-6
Chemical Formula: C25H42O5
Exact Mass: 422.30
Molecular Weight: 422.600
Elemental Analysis: C, 71.05; H, 10.02; O, 18.93
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Synonym: L 647318; L-647318; L647318; L-647,318; L 647,318; L647,318;
IUPAC/Chemical Name: (1S,3S,4aS,7S,8S,8aS)-8-(2-((2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyldecahydronaphthalen-1-yl 2,2-dimethylbutanoate
InChi Key: RCXGNJNDQYAWDC-DNOMIITOSA-N
InChi Code: InChI=1S/C25H42O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h15-21,23,26H,6-14H2,1-5H3/t15-,16-,17-,18+,19+,20-,21-,23-/m0/s1
SMILES Code: CCC(C)(C)C(O[C@H]1C[C@@H](C)C[C@]2([H])CC[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(O3)=O)[C@@]12[H])=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 422.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Smith PF, Eydelloth RS, Grossman SJ, Stubbs RJ, Schwartz MS, Germershausen JI, MacDonald JS. Myopathy associated with HMG-CoA reductase inhibitors (HMGRIs) and cyclosporin A: evaluation in a rat model. Eur Heart J. 1992 Jul;13 Suppl B:2-6. PubMed PMID: 1644096.
2: Smith PF, Eydelloth RS, Grossman SJ, Stubbs RJ, Schwartz MS, Germershausen JI, Vyas KP, Kari PH, MacDonald JS. HMG-CoA reductase inhibitor-induced myopathy in the rat: cyclosporine A interaction and mechanism studies. J Pharmacol Exp Ther. 1991 Jun;257(3):1225-35. PubMed PMID: 1904494.
3: Kaufman MJ. Applications of oxygen polarography to drug stability testing and formulation development: solution-phase oxidation of hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitors. Pharm Res. 1990 Mar;7(3):289-92. PubMed PMID: 2339104.