TCS-2002
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    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H555261

CAS#: 1005201-24-0

Description: TCS-2002 is a Potent inhibitor of GSK-3β (IC50 = 35 nM). Oral adminstration inhibits cold water stress-induced tau hyperphosphorylation in the mouse brain.

Chemical Structure

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TCS-2002
CAS# 1005201-24-0
Instruction

Theoretical Analysis

Hodoodo Cat#: H555261
Name: TCS-2002
CAS#: 1005201-24-0
Chemical Formula: C18H14N2O3S
Exact Mass: 338.07
Molecular Weight: 338.381
Elemental Analysis: C, 63.89; H, 4.17; N, 8.28; O, 14.18; S, 9.47

Price and Availability

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10mg USD 375
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Synonym: TCS-2002; TCS 2002; TCS2002.

IUPAC/Chemical Name: 2-Methyl-5-[3-[4-(methylsulfinyl)phenyl]-5-benzofuranyl]-1,3,4-oxadiazole

InChi Key: RCKYSTKYIVULEK-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H14N2O3S/c1-11-19-20-18(23-11)13-5-8-17-15(9-13)16(10-22-17)12-3-6-14(7-4-12)24(2)21/h3-10H,1-2H3

SMILES Code: O=S(C1=CC=C(C2=COC3=CC=C(C4=NN=C(C)O4)C=C23)C=C1)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 338.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Saitoh et al (2009) 2-{3-[4-(alkylsulfinyl)phenyl]-1-benzofuran-5-yl}-5-methyl-1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3β with good brain permeability. J.Med.Chem. 52 6270 PMID: 19775160