WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H596606
CAS#: 119742-06-2
Description: L 659286 is a cephalosporin derivative.
Hodoodo Cat#: H596606
Name: L 659286
CAS#: 119742-06-2
Chemical Formula: C17H21N5O7S2
Exact Mass: 471.09
Molecular Weight: 471.500
Elemental Analysis: C, 43.31; H, 4.49; N, 14.85; O, 23.75; S, 13.60
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Synonym: L 659286; L-659286; L659286; L-659,286; L 659,286; L659,286;
IUPAC/Chemical Name: 3-((((6R,7S)-7-methoxy-5,5-dioxido-8-oxo-2-(pyrrolidine-1-carbonyl)-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl)methyl)thio)-2-methyl-1,2-dihydro-1,2,4-triazine-5,6-dione
InChi Key: CSHLZLLBIGKRRN-MEDUHNTESA-N
InChi Code: InChI=1S/C17H21N5O7S2/c1-20-17(18-12(23)13(24)19-20)30-7-9-8-31(27,28)16-11(29-2)15(26)22(16)10(9)14(25)21-5-3-4-6-21/h11,16H,3-8H2,1-2H3,(H,19,24)/t11-,16+/m0/s1
SMILES Code: O=C(N1CCCC1)C(N2C3=O)=C(CSC(N(C)NC4=O)=NC4=O)CS([C@]2([H])[C@H]3OC)(=O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 471.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Knight WB, Maycock AL, Green BG, Ashe BM, Gale P, Weston H, Finke PE, Hagmann WK, Shah SK, Doherty JB. Mechanism of inhibition of human leukocyte elastase by two cephalosporin derivatives. Biochemistry. 1992 Jun 2;31(21):4980-6. PubMed PMID: 1599924.
2: Green BG, Weston H, Ashe BM, Doherty J, Finke P, Hagmann W, Lark M, Mao J, Maycock A, Moore V, et al. PMN elastases: a comparison of the specificity of human isozymes and the enzyme from other species toward substrates and inhibitors. Arch Biochem Biophys. 1991 Apr;286(1):284-92. PubMed PMID: 1897955.
3: Davies P, Ashe BM, Bonney RJ, Dorn C, Finke P, Fletcher D, Hanlon WA, Humes JL, Maycock A, Mumford RA, et al. The discovery and biologic properties of cephalosporin-based inhibitors of PMN elastase. Ann N Y Acad Sci. 1991;624:219-29. Review. PubMed PMID: 2064223.
4: Bonney RJ, Ashe B, Maycock A, Dellea P, Hand K, Osinga D, Fletcher D, Mumford R, Davies P, Frankenfield D, et al. Pharmacological profile of the substituted beta-lactam L-659,286: a member of a new class of human PMN elastase inhibitors. J Cell Biochem. 1989 Jan;39(1):47-53. PubMed PMID: 2497109.