WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H562910
CAS#: 1430330-65-6
Description: HJC0149 is a potent orally bioavailable inhibitor of signal transducer and activator of transcription 3 (STAT3).
Hodoodo Cat#: H562910
Name: HJC0149
CAS#: 1430330-65-6
Chemical Formula: C15H10ClNO4S
Exact Mass: 335.00
Molecular Weight: 335.750
Elemental Analysis: C, 53.66; H, 3.00; Cl, 10.56; N, 4.17; O, 19.06; S, 9.55
This product is not in stock, which may be available by custom synthesis.
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Synonym: HJC0149; HJC-0149; HJC 0149;
IUPAC/Chemical Name: 5-chloro-N-(1,1-dioxidobenzo[b]thiophen-6-yl)-2-hydroxybenzamide
InChi Key: ZILFZUFDNNFSHO-UHFFFAOYSA-N
InChi Code: InChI=1S/C15H10ClNO4S/c16-10-2-4-13(18)12(7-10)15(19)17-11-3-1-9-5-6-22(20,21)14(9)8-11/h1-8,18H,(H,17,19)
SMILES Code: OC1=C(C(NC2=CC3=C(C=CS3(=O)=O)C=C2)=O)C=C(Cl)C=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 335.75 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Chen H, Yang Z, Ding C, Xiong A, Wild C, Wang L, Ye N, Cai G, Flores RM, Ding Y, Shen Q, Zhou J. Discovery of potent anticancer agent HJC0416, an orally bioavailable small molecule inhibitor of signal transducer and activator of transcription 3 (STAT3). Eur J Med Chem. 2014 Jul 23;82:195-203. doi: 10.1016/j.ejmech.2014.05.049. Epub 2014 May 22. PubMed PMID: 24904966; PubMed Central PMCID: PMC4096847.