ML-193
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    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H555262

CAS#: 713121-80-3

Description: ML-193, also known as CID 1261822, is a potent antagonist of GPR55 (IC50 = 221 nM).

Chemical Structure

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ML-193
CAS# 713121-80-3
Instruction

Theoretical Analysis

Hodoodo Cat#: H555262
Name: ML-193
CAS#: 713121-80-3
Chemical Formula: C28H25N5O4S
Exact Mass: 527.16
Molecular Weight: 527.599
Elemental Analysis: C, 63.74; H, 4.78; N, 13.27; O, 12.13; S, 6.08

Price and Availability

Size Price Availability Quantity
10mg USD 150 2 Weeks
25mg USD 250 2 Weeks
50mg USD 450 2 Weeks
100mg USD 750 2 Weeks
200mg USD 1250 2 Weeks
500mg USD 2250 2 Weeks
1g USD 3250 2 Weeks
2g USD 5450 2 Weeks
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Synonym: ML-193; ML 193; ML193; CID 1261822; CID-1261822; CID1261822.

IUPAC/Chemical Name: N-[4-[[(3,4-Dimethyl-5-isoxazolyl)amino]sulfonyl]phenyl]-6,8-dimethyl-2-(2-pyridinyl)-4-quinolinecarboxamide

InChi Key: HTSLEZOTMYUPLU-UHFFFAOYSA-N

InChi Code: InChI=1S/C28H25N5O4S/c1-16-13-17(2)26-22(14-16)23(15-25(31-26)24-7-5-6-12-29-24)27(34)30-20-8-10-21(11-9-20)38(35,36)33-28-18(3)19(4)32-37-28/h5-15,33H,1-4H3,(H,30,34)

SMILES Code: O=C(C1=CC(C2=NC=CC=C2)=NC3=C(C)C=C(C)C=C13)NC4=CC=C(S(=O)(NC5=C(C)C(C)=NO5)=O)C=C4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 52.8 100.00

Preparing Stock Solutions

The following data is based on the product molecular weight 527.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Leo LM, Familusi B, Hoang M, Smith R, Lindenau K, Sporici KT, Brailoiu E, Abood ME, Brailoiu GC. GPR55-mediated effects on brain microvascular endothelial cells and the blood-brain barrier. Neuroscience. 2019 Aug 21;414:88-98. doi: 10.1016/j.neuroscience.2019.06.039. Epub 2019 Jul 4. PMID: 31279825; PMCID: PMC6684354.


2: Deliu E, Sperow M, Console-Bram L, Carter RL, Tilley DG, Kalamarides DJ, Kirby LG, Brailoiu GC, Brailoiu E, Benamar K, Abood ME. The Lysophosphatidylinositol Receptor GPR55 Modulates Pain Perception in the Periaqueductal Gray. Mol Pharmacol. 2015 Aug;88(2):265-72. doi: 10.1124/mol.115.099333. Epub 2015 May 13. PMID: 25972448; PMCID: PMC4518086..