WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H555264
CAS#: Unknown
Description: Q151 is a IMPDH) Inhibitor as a potential Antituberculosis Agent.
Hodoodo Cat#: H555264
Name: Q151
CAS#: Unknown
Chemical Formula: C23H16F2N4O2
Exact Mass: 418.12
Molecular Weight: 418.404
Elemental Analysis: C, 66.03; H, 3.85; F, 9.08; N, 13.39; O, 7.65
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Synonym: Q151; Q-151; Q 151;
IUPAC/Chemical Name: (S)-N-(2-(4-Cyanophenyl)benzo[d]oxazol-5-yl)-2-((2,3-difluorophenyl)amino)propanamide
InChi Key: QUSYLBPSSGPXBL-ZDUSSCGKSA-N
InChi Code: InChI=1S/C23H16F2N4O2/c1-13(27-18-4-2-3-17(24)21(18)25)22(30)28-16-9-10-20-19(11-16)29-23(31-20)15-7-5-14(12-26)6-8-15/h2-11,13,27H,1H3,(H,28,30)/t13-/m0/s1
SMILES Code: C[C@H](NC1=CC=CC(F)=C1F)C(NC2=CC=C(OC(C3=CC=C(C#N)C=C3)=N4)C4=C2)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info: Mycobacterium tuberculosis (Mtb) inosine 5′-monophosphate dehydrogenase 2 (MtbIMPDH2) is a promising yet controversial potential target. The inhibition of MtbIMPDH2 blocks the biosynthesis of guanine nucleotides, but high concentrations of guanine can potentially rescue the bacteria.
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 418.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
Expanding Benzoxazole-Based Inosine 5′-Monophosphate Dehydrogenase (IMPDH) Inhibitor Structure–Activity As Potential Antituberculosis Agents
Shibin Chacko, Helena I. M. Boshoff, Vinayak Singh, Davide M. Ferraris, Deviprasad R. Gollapalli, Minjia Zhang, Ann P. Lawson, Michael J. Pepi, Andrzej Joachimiak, Menico Rizzi, Valerie Mizrahi, Gregory D. Cuny, and Lizbeth Hedstrom
Publication Date (Web): May 10, 2018 (Article)
DOI: 10.1021/acs.jmedchem.7b01839