WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H596619
CAS#: 130007-52-2
Description: L 669083 is a photoaffinity analogue of two classes of potent leukotriene biosynthesis inhibitors.
Hodoodo Cat#: H596619
Name: L 669083
CAS#: 130007-52-2
Chemical Formula: C29H29IN4O5S
Exact Mass: 672.09
Molecular Weight: 672.530
Elemental Analysis: C, 51.79; H, 4.35; I, 18.87; N, 8.33; O, 11.89; S, 4.77
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.
Synonym: L 669083; L-669083; L669083; L-669,083; L 669,083; L669,083;
IUPAC/Chemical Name: 3-(3-((4-azidophenyl)sulfonyl)-1-(4-hydroxy-3-iodobenzyl)-5-isopropyl-1H-indol-2-yl)-2,2-dimethylpropanoic acid
InChi Key: AKCMQYDDRKIENA-UHFFFAOYSA-N
InChi Code: InChI=1S/C29H29IN4O5S/c1-17(2)19-6-11-24-22(14-19)27(40(38,39)21-9-7-20(8-10-21)32-33-31)25(15-29(3,4)28(36)37)34(24)16-18-5-12-26(35)23(30)13-18/h5-14,17,35H,15-16H2,1-4H3,(H,36,37)
SMILES Code: O=C(O)C(C)(C)CC(N1CC2=CC=C(O)C(I)=C2)=C(S(=O)(C3=CC=C(N=[N+]=[N-])C=C3)=O)C4=C1C=CC(C(C)C)=C4
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 672.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Vickers PJ, Adam M, Charleson S, Coppolino MG, Evans JF, Mancini JA. Identification of amino acid residues of 5-lipoxygenase-activating protein essential for the binding of leukotriene biosynthesis inhibitors. Mol Pharmacol. 1992 Jul;42(1):94-102. PubMed PMID: 1635556.
2: Mancini JA, Prasit P, Coppolino MG, Charleson P, Leger S, Evans JF, Gillard JW, Vickers PJ. 5-Lipoxygenase-activating protein is the target of a novel hybrid of two classes of leukotriene biosynthesis inhibitors. Mol Pharmacol. 1992 Feb;41(2):267-72. PubMed PMID: 1538707.
3: Reid GK, Kargman S, Vickers PJ, Mancini JA, Léveillé C, Ethier D, Miller DK, Gillard JW, Dixon RA, Evans JF. Correlation between expression of 5-lipoxygenase-activating protein, 5-lipoxygenase, and cellular leukotriene synthesis. J Biol Chem. 1990 Nov 15;265(32):19818-23. PubMed PMID: 2174053.
4: Miller DK, Gillard JW, Vickers PJ, Sadowski S, Léveillé C, Mancini JA, Charleson P, Dixon RA, Ford-Hutchinson AW, Fortin R, et al. Identification and isolation of a membrane protein necessary for leukotriene production. Nature. 1990 Jan 18;343(6255):278-81. PubMed PMID: 2300172.
