WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H591359
CAS#: 122520-79-0
Description: An antimicrobial peptide with angiogenic properties, AG-30/5C, activates human mast cells through the MAPK and NF-κB pathways.
Hodoodo Cat#: H591359
Name: AG 30
CAS#: 122520-79-0
Chemical Formula: C10H7NO4
Exact Mass: 205.04
Molecular Weight: 205.170
Elemental Analysis: C, 58.54; H, 3.44; N, 6.83; O, 31.19
Synonym: AG 30; AG-30; AG30; Tyrphostin AG30;
IUPAC/Chemical Name: 2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (E)-
InChi Key: CJMWBHLWSMKFSM-XVNBXDOJSA-N
InChi Code: InChI=1S/C10H7NO4/c11-5-7(10(14)15)3-6-1-2-8(12)9(13)4-6/h1-4,12-13H,(H,14,15)/b7-3+
SMILES Code: O=C(O)/C(C#N)=C/C1=CC=C(O)C(O)=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 205.17 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Roy S, Ganguly A, Haque M, Ali H. Angiogenic Host Defense Peptide AG-30/5C and Bradykinin B2 Receptor Antagonist Icatibant Are G Protein Biased Agonists for MRGPRX2 in Mast Cells. J Immunol. 2019 Feb 15;202(4):1229-1238. doi: 10.4049/jimmunol.1801227. Epub 2019 Jan 16. PMID: 30651343; PMCID: PMC6369923.
2: Kiatsurayanon C, Niyonsaba F, Chieosilapatham P, Okumura K, Ikeda S, Ogawa H. Angiogenic peptide (AG)-30/5C activates human keratinocytes to produce cytokines/chemokines and to migrate and proliferate via MrgX receptors. J Dermatol Sci. 2016 Sep;83(3):190-9. doi: 10.1016/j.jdermsci.2016.05.006. Epub 2016 May 11. PMID: 27237787.
3: Kanazawa K, Okumura K, Ogawa H, Niyonsaba F. An antimicrobial peptide with angiogenic properties, AG-30/5C, activates human mast cells through the MAPK and NF-κB pathways. Immunol Res. 2016 Apr;64(2):594-603. doi: 10.1007/s12026-015-8759-5. PMID: 26663017.
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