WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H571918
CAS#: 54149-49-4
Description: Aminooxy-PEG2-methane is a PEG derivative containing an aminooxy group and a methane group. The aminooxy group can be used in bioconjugation. It reacts with an aldehyde to form an oxime bond. If a reductant is used, it will form a hydroxylamine linkage. PEG Linkers may be useful in the development of antibody drug conjugates and drug delivery methods.
Hodoodo Cat#: H571918
Name: Aminooxy-PEG2-methane
CAS#: 54149-49-4
Chemical Formula: C5H13NO3
Exact Mass: 135.09
Molecular Weight: 135.160
Elemental Analysis: C, 44.43; H, 9.69; N, 10.36; O, 35.51
Synonym: Aminooxy-PEG2-methane
IUPAC/Chemical Name: O-(2-(2-methoxyethoxy)ethyl)hydroxylamine
InChi Key: VKTXNKVXALMHFI-UHFFFAOYSA-N
InChi Code: InChI=1S/C5H13NO3/c1-7-2-3-8-4-5-9-6/h2-6H2,1H3
SMILES Code: NOCCOCCOC
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info: The hydrophilic PEG spacer increases solubility in aqueous media.
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 135.16 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
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6: Rashidian M, Kumarapperuma SC, Gabrielse K, Fegan A, Wagner CR, Distefano MD. Simultaneous dual protein labeling using a triorthogonal reagent. J Am Chem Soc. 2013 Nov 6;135(44):16388-96. doi: 10.1021/ja403813b. Epub 2013 Oct 17. PubMed PMID: 24134212; PubMed Central PMCID: PMC3873327.
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