WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H562941
CAS#: 256348-71-7
Description: PAO-PDT is a highly selective small molecule inhibitor of thioredoxin reductase (TrxR).
Hodoodo Cat#: H562941
Name: PAO-PDT
CAS#: 256348-71-7
Chemical Formula: C9H12AsNS2
Exact Mass: 272.96
Molecular Weight: 273.240
Elemental Analysis: C, 39.56; H, 4.43; As, 27.42; N, 5.13; S, 23.47
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Synonym: PAO-PDT; PAO PDT; PAOPDT;
IUPAC/Chemical Name: 2-(4-Aminophenyl)-1,3,2-dithiarsinane
InChi Key: WONBTYJJKXSAKA-UHFFFAOYSA-N
InChi Code: InChI=1S/C9H12AsNS2/c11-9-4-2-8(3-5-9)10-12-6-1-7-13-10/h2-5H,1,6-7,11H2
SMILES Code: NC1=CC=C([As]2SCCCS2)C=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 273.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Fan XY, Liu YJ, Chen K, Jiang FL, Hu YJ, Liu D, Liu Y, Ge YS. Organic arsenicals target thioredoxin reductase followed by oxidative stress and mitochondrial dysfunction resulting in apoptosis. Eur J Med Chem. 2018 Jan 1;143:1090-1102. doi: 10.1016/j.ejmech.2017.05.022. Epub 2017 May 6. PubMed PMID: 29150332.
2: Liu Y, Duan D, Yao J, Zhang B, Peng S, Ma H, Song Y, Fang J. Dithiaarsanes induce oxidative stress-mediated apoptosis in HL-60 cells by selectively targeting thioredoxin reductase. J Med Chem. 2014 Jun 26;57(12):5203-11. doi: 10.1021/jm500221p. Epub 2014 Jun 11. PubMed PMID: 24867309.