WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H562947
CAS#: 856435-40-0
Description: MDM2-p53-IN-1b is an inhibitor of the MDM2-p53 interaction.
Hodoodo Cat#: H562947
Name: MDM2-p53-IN-1b
CAS#: 856435-40-0
Chemical Formula: C17H15NO3
Exact Mass: 281.11
Molecular Weight: 281.310
Elemental Analysis: C, 72.58; H, 5.37; N, 4.98; O, 17.06
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Synonym: MDM2-p53-IN-1b; MDM2 p53 IN 1b; MDM2p53IN1b; MDM2-p53 inhibitor 1b;
IUPAC/Chemical Name: (3E)-3-[(2,4-dimethoxyphenyl)methylene]-1,3-dihydro-2H-indol-2-one
InChi Key: PSRHWNITWXEJJW-NTEUORMPSA-N
InChi Code: InChI=1S/C17H15NO3/c1-20-12-8-7-11(16(10-12)21-2)9-14-13-5-3-4-6-15(13)18-17(14)19/h3-10H,1-2H3,(H,18,19)/b14-9+
SMILES Code: O=C1NC2=C(C=CC=C2)/C1=C\C3=CC=C(OC)C=C3OC
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 281.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Boyarskikh UA, Shadrina AS, Smetanina MA, Tsepilov YA, Oscorbin IP, Kozlov VV, Kel AE, Filipenko ML. Mycoplasma hyorhinis reduces sensitivity of human lung carcinoma cells to Nutlin-3 and promotes their malignant phenotype. J Cancer Res Clin Oncol. 2018 May 8. doi: 10.1007/s00432-018-2658-9. [Epub ahead of print] PubMed PMID: 29737431.
2: Uesato S, Matsuura Y, Matsue S, Sumiyoshi T, Hirata Y, Takemoto S, Kawaratani Y, Yamai Y, Ishida K, Sasaki T, Enari M. Discovery of new low-molecular-weight p53-Mdmx disruptors and their anti-cancer activities. Bioorg Med Chem. 2016 Apr 15;24(8):1919-26. doi: 10.1016/j.bmc.2016.03.021. Epub 2016 Mar 11. PubMed PMID: 27010502.
3: Hailfinger S, Jaworski M, Marx-Stoelting P, Wanke I, Schwarz M. Regulation of P53 stability in p53 mutated human and mouse hepatoma cells. Int J Cancer. 2007 Apr 1;120(7):1459-64. PubMed PMID: 17205518.