NUC-3373

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H596786

CAS#: 1332837-31-6

Description: NUC-3373 is a potent cancel stem cell inhibitor. NUC-3373 has preferential cytotoxic effects on leukemic stem cells (LSCs). In vitro data confirmed that NUC-3373 exerts its cytotoxic activity independently of thymidine kinase in TK-deficient tumor cell lines, and it is resistant to degradative action by catabolic enzymes including TP and DPD.19 In addition, NUC-3373 was found to generate 366- fold higher intracellular levels of the active monophosphate form, FdUMP, in the human colorectal cancer cell line HT29 compared with 5-FU and achieved significantly greater tumor volume reduction than 5-FU in HT29 xenograft studies.


Chemical Structure

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NUC-3373
CAS# 1332837-31-6

Theoretical Analysis

Hodoodo Cat#: H596786
Name: NUC-3373
CAS#: 1332837-31-6
Chemical Formula: C29H30F2N4O8P
Exact Mass: 631.18
Molecular Weight: 631.540
Elemental Analysis: C, 55.15; H, 4.79; F, 6.02; N, 8.87; O, 20.27; P, 4.90

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: NUC-3373; NUC 3373; NUC3373; Fosifloxuridine nafalbenamide;

IUPAC/Chemical Name: L-Alanine, N-(-2'-deoxy-2',2'-difluoro-p-1-naphthalenyl-5'-cytidylyl)-, phenylmethyl ester

InChi Key: LYMGFDGRLCYHTR-ICIRLHQFSA-N

InChi Code: InChI=1S/C29H30F2N4O8P/c1-18(26(37)41-16-19-8-3-2-4-9-19)34-44(39,40,23-13-7-11-20-10-5-6-12-21(20)23)42-17-22-25(36)29(30,31)27(43-22)35-15-14-24(32)33-28(35)38/h2-15,18,22,25,27,36H,16-17H2,1H3,(H2,32,33,38)(H2,34,39,40)/t18-,22+,25+,27+/m0/s1

SMILES Code: C[C@@H](C(OCC1=CC=CC=C1)=O)NP(OC[C@@H]2[C@H](C(F)(F)[C@H](N3C(N=C(C=C3)N)=O)O2)O)(O)(C4=C5C=CC=CC5=CC=C4)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 631.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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