WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H596786
CAS#: 1332837-31-6
Description: NUC-3373 is a potent cancel stem cell inhibitor. NUC-3373 has preferential cytotoxic effects on leukemic stem cells (LSCs). In vitro data confirmed that NUC-3373 exerts its cytotoxic activity independently of thymidine kinase in TK-deficient tumor cell lines, and it is resistant to degradative action by catabolic enzymes including TP and DPD.19 In addition, NUC-3373 was found to generate 366- fold higher intracellular levels of the active monophosphate form, FdUMP, in the human colorectal cancer cell line HT29 compared with 5-FU and achieved significantly greater tumor volume reduction than 5-FU in HT29 xenograft studies.
Hodoodo Cat#: H596786
Name: NUC-3373
CAS#: 1332837-31-6
Chemical Formula: C29H30F2N4O8P
Exact Mass: 631.18
Molecular Weight: 631.540
Elemental Analysis: C, 55.15; H, 4.79; F, 6.02; N, 8.87; O, 20.27; P, 4.90
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Synonym: NUC-3373; NUC 3373; NUC3373; Fosifloxuridine nafalbenamide;
IUPAC/Chemical Name: L-Alanine, N-(-2'-deoxy-2',2'-difluoro-p-1-naphthalenyl-5'-cytidylyl)-, phenylmethyl ester
InChi Key: LYMGFDGRLCYHTR-ICIRLHQFSA-N
InChi Code: InChI=1S/C29H30F2N4O8P/c1-18(26(37)41-16-19-8-3-2-4-9-19)34-44(39,40,23-13-7-11-20-10-5-6-12-21(20)23)42-17-22-25(36)29(30,31)27(43-22)35-15-14-24(32)33-28(35)38/h2-15,18,22,25,27,36H,16-17H2,1H3,(H2,32,33,38)(H2,34,39,40)/t18-,22+,25+,27+/m0/s1
SMILES Code: C[C@@H](C(OCC1=CC=CC=C1)=O)NP(OC[C@@H]2[C@H](C(F)(F)[C@H](N3C(N=C(C=C3)N)=O)O2)O)(O)(C4=C5C=CC=CC5=CC=C4)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 631.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |