WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H596795
CAS#: 156039-69-9
Description: Mixanpril is a lipophilic prodrug of RB 105.
Hodoodo Cat#: H596795
Name: Mixanpril
CAS#: 156039-69-9
Chemical Formula: C21H23NO4S
Exact Mass: 385.13
Molecular Weight: 385.470
Elemental Analysis: C, 65.43; H, 6.01; N, 3.63; O, 16.60; S, 8.32
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Synonym: Mixanpril;
IUPAC/Chemical Name: ((2S,3R)-2-((benzoylthio)methyl)-3-phenylbutanoyl)-L-alanine
InChi Key: GKYIONYOYVKKQI-MPGHIAIKSA-N
InChi Code: InChI=1S/C21H23NO4S/c1-14(16-9-5-3-6-10-16)18(19(23)22-15(2)20(24)25)13-27-21(26)17-11-7-4-8-12-17/h3-12,14-15,18H,13H2,1-2H3,(H,22,23)(H,24,25)/t14-,15-,18-/m0/s1
SMILES Code: C[C@@H](C(O)=O)NC([C@@H](CSC(C1=CC=CC=C1)=O)[C@H](C2=CC=CC=C2)C)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 385.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Lassila M, Davis BJ, Allen TJ, Burrell LM, Cooper ME, Cao Z. Cardiovascular hypertrophy in diabetic spontaneously hypertensive rats: optimizing blockade of the renin-angiotensin system. Clin Sci (Lond). 2003 Apr;104(4):341-7. PubMed PMID: 12653675.
2: Arbin V, Claperon N, Fournié-Zaluski MC, Roques BP, Peyroux J. Effects of dual angiotensin-converting enzyme and neutral endopeptidase 24-11 chronic inhibition by mixanpril on insulin sensitivity in lean and obese Zucker rats. J Cardiovasc Pharmacol. 2003 Feb;41(2):254-64. PubMed PMID: 12548087.
3: Arbin V, Claperon N, Fournié-Zaluski MC, Roques BP, Peyroux J. Acute effect of the dual angiotensin-converting enzyme and neutral endopeptidase 24-11 inhibitor mixanpril on insulin sensitivity in obese Zucker rat. Br J Pharmacol. 2001 Jun;133(4):495-502. PubMed PMID: 11399666; PubMed Central PMCID: PMC1572809.
4: Fournié-Zaluski MC, Gonzalez W, Turcaud S, Pham I, Roques BP, Michel JB. Dual inhibition of angiotensin-converting enzyme and neutral endopeptidase by the orally active inhibitor mixanpril: a potential therapeutic approach in hypertension. Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):4072-6. PubMed PMID: 8171037; PubMed Central PMCID: PMC43725.
5: Fournié-Zaluski MC, Coric P, Turcaud S, Rousselet N, Gonzalez W, Barbe B, Pham I, Jullian N, Michel JB, Roques BP. New dual inhibitors of neutral endopeptidase and angiotensin-converting enzyme: rational design, bioavailability, and pharmacological responses in experimental hypertension. J Med Chem. 1994 Apr 15;37(8):1070-83. PubMed PMID: 8164250.