WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H562955
CAS#: 850715-59-2
Description: SAMT-247 is an inhibitor of HIV. It acts by modifying the nucleocapsid NCp7 region of Gag in infected cells and blocking Gag processing and reducing infectivity.
Hodoodo Cat#: H562955
Name: SAMT-247
CAS#: 850715-59-2
Chemical Formula: C12H14N2O2S
Exact Mass: 250.08
Molecular Weight: 250.310
Elemental Analysis: C, 57.58; H, 5.64; N, 11.19; O, 12.78; S, 12.81
Synonym: SAMT-247; SAMT 247; SAMT247;
IUPAC/Chemical Name: N-[2-Acetylthiobenzoyl]-beta-alaninamide
InChi Key: VBQYEICOHVAOSJ-UHFFFAOYSA-N
InChi Code: InChI=1S/C12H14N2O2S/c1-8(15)9-4-2-3-5-10(9)12(17)14-7-6-11(13)16/h2-5H,6-7H2,1H3,(H2,13,16)(H,14,17)
SMILES Code: O=C(N)CCNC(C1=CC=CC=C1C(C)=O)=S
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 250.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Nikolayevskiy H, Scerba MT, Deschamps JR, Appella DH. Reaction Kinetics Direct a Rational Synthesis of an HIV-1 Inactivator of Nucleocapsid Protein 7 and Provide Mechanistic Insight into Cellular Metabolism and Antiviral Activity. Chemistry. 2018 Apr 13. doi: 10.1002/chem.201801253. [Epub ahead of print] PubMed PMID: 29653024.
