WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H596833
CAS#: 129228-52-0
Description: Snf 8702 is a selective radioligand for CCKB receptors.
Hodoodo Cat#: H596833
Name: Snf 8702
CAS#: 129228-52-0
Chemical Formula: C53H70N10O13
Exact Mass: 1,054.51
Molecular Weight: 1,055.200
Elemental Analysis: C, 60.33; H, 6.69; N, 13.27; O, 19.71
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Synonym: Snf 8702; Snf-8702; Snf8702;
IUPAC/Chemical Name: (3S,6S,9S,15S,18S,21S)-9-((1H-indol-3-yl)methyl)-21-amino-3-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)carbamoyl)-6,15-dibutyl-18-(4-hydroxybenzyl)-7,16-dimethyl-5,8,11,14,17,20-hexaoxo-4,7,10,13,16,19-hexaazatricosanedioic acid
InChi Key: JUKSSJWDVMBURS-TZLMNZOISA-N
InChi Code: InChI=1S/C53H70N10O13/c1-5-7-18-42(62(3)52(75)40(25-32-20-22-34(64)23-21-32)61-48(71)36(54)27-45(66)67)50(73)57-30-44(65)58-41(26-33-29-56-37-17-13-12-16-35(33)37)53(76)63(4)43(19-8-6-2)51(74)60-39(28-46(68)69)49(72)59-38(47(55)70)24-31-14-10-9-11-15-31/h9-17,20-23,29,36,38-43,56,64H,5-8,18-19,24-28,30,54H2,1-4H3,(H2,55,70)(H,57,73)(H,58,65)(H,59,72)(H,60,74)(H,61,71)(H,66,67)(H,68,69)/t36-,38-,39-,40-,41-,42-,43-/m0/s1
SMILES Code: O=C(N)[C@H](CC1=CC=CC=C1)NC([C@H](CC(O)=O)NC([C@H](CCCC)N(C([C@H](CC2=CNC3=C2C=CC=C3)NC(CNC([C@H](CCCC)N(C([C@H](CC4=CC=C(O)C=C4)NC([C@H](CC(O)=O)N)=O)=O)C)=O)=O)=O)C)=O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 1,055.20 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Gronier B, Debonnel G. CCKB receptors mediate CCK-8S-induced activation of dorsal hippocampus CA3 pyramidal neurons: an in vivo electrophysiological study in the rat. Synapse. 1995 Oct;21(2):158-68. PubMed PMID: 8584977.
2: Malatynska E, Knapp RJ, Stropova D, Varga E, Yamamura HI. The role of the Val353 residue in antagonist binding to rat CCK-B receptors. Neuroreport. 1995 Jun 19;6(9):1325-9. PubMed PMID: 7669996.
3: Slaninova J, Knapp RJ, Weber SJ, Davis TP, Fang SN, Hruby VJ, Yamamura HI. [125I]SNF 8702: a selective radioligand for CCKB receptors. Peptides. 1995;16(2):221-4. PubMed PMID: 7784252.
4: Knapp RJ, Malatynska E, Peterson P, Zalewska T, Fang S, Hruby VJ, Smith TL, Yamamura HI. [N-methylnorleucine-(28,31)]cholecystokinin-(26-33) (SNF 8702) activity at a cloned rat CCKB receptor. Eur J Pharmacol. 1994 Oct 14;269(2):133-8. PubMed PMID: 7851490.
5: Knapp RJ, Malatynska E, Hashimoto S, Fang S, Hunt M, Wamsley JK, Peterson P, Zalewska T, Hruby VJ, Yamamura HI. [3H]SNF8702 autoradiography of CCK-B receptors in guinea pig brain and studies with a cloned rat CCK-B receptor. Ann N Y Acad Sci. 1994 Mar 23;713:380-3. PubMed PMID: 8185194.
6: Durieux C, Ruiz-Gayo M, Corringer PJ, Bergeron F, Ducos B, Roques BP. [3H]pBC 264, a suitable probe for studying cholecystokinin-B receptors: binding characteristics in rodent brains and comparison with [3H]SNF 8702. Mol Pharmacol. 1992 Jun;41(6):1089-95. PubMed PMID: 1614411.
7: Ayres EA, Parkhurst DN, Fang S, Kramer TH, Hruby VJ, Burks TF. Antinociceptive and gastrointestinal transit effects of cholecystokinin (CCK-8) and related analogs of CCK-8 in the mouse. Proc West Pharmacol Soc. 1991;34:477-84. PubMed PMID: 1788334.
8: Knapp RJ, Vaughn LK, Fang SN, Bogert CL, Yamamura MS, Hruby VJ, Yamamura HI. A new, highly selective CCK-B receptor radioligand ([3H][N-methyl-Nle28,31]CCK26-33): evidence for CCK-B receptor heterogeneity. J Pharmacol Exp Ther. 1990 Dec;255(3):1278-86. PubMed PMID: 2262906.
