WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H581253
CAS#: 35838-63-2
Description: Clocoumarol is an anticoagulants, an agents that prevent blood clotting. It can inhibit the dilatation of the spleen and the congestion of lymph nodes.
Hodoodo Cat#: H581253
Name: Clocoumarol
CAS#: 35838-63-2
Chemical Formula: C21H21ClO3
Exact Mass: 356.12
Molecular Weight: 356.850
Elemental Analysis: C, 70.68; H, 5.93; Cl, 9.93; O, 13.45
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Synonym: Clocoumarol; Clocoumarolum; DB 112; BRN 1264788;
IUPAC/Chemical Name: 3-(p-(2-Chloroethyl)-alpha-propylbenzyl)-4-hydroxycoumarin
InChi Key: XEBSDNCEYSPGIU-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H21ClO3/c1-2-5-16(15-10-8-14(9-11-15)12-13-22)19-20(23)17-6-3-4-7-18(17)25-21(19)24/h3-4,6-11,16,23H,2,5,12-13H2,1H3
SMILES Code: O=C1OC2=C(C=CC=C2)C(O)=C1C(CCC)C3=CC=C(CCCl)C=C3
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 356.85 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Thonnart N, Vanhaelen M, Vanhaelen-Fastré R. In vitro metabolism of clocoumarol, a new 4-hydroxycoumarin anticoagulant; identification of two additional metabolites. Drug Metab Dispos. 1979 Nov-Dec;7(6):449-50. PubMed PMID: 43239.
2. The thrombopenic effect of ellagic acid in the rat. Another model of platelet stimulation "in vivo". Joana Damas, Gaby Remacle-VolonThrombosis research 1987.
3. Mechanism of the congestion of lymph nodes induced by ellagic acid in rats. Joana Damas, Gaby Remacle-Volon, Azaria Amelia AdamAgents and Actions 1987.