SJ3366

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H562973

CAS#: 195720-26-4

Description: SJ3366 is a unique and highly potent nonnucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1 (HIV-1) and HIV-2.


Chemical Structure

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SJ3366
CAS# 195720-26-4

Theoretical Analysis

Hodoodo Cat#: H562973
Name: SJ3366
CAS#: 195720-26-4
Chemical Formula: C21H24N2O3
Exact Mass: 352.18
Molecular Weight: 352.430
Elemental Analysis: C, 71.57; H, 6.86; N, 7.95; O, 13.62

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: SJ3366; SJ-3366; SJ 3366;

IUPAC/Chemical Name: 1-(Cyclopent-3-en-1-ylmethyl)-6-(3,5-dimethylbenzoyl)-5-ethylpyrimidine-2,4-dione

InChi Key: BEMROAADXJFLBI-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H24N2O3/c1-4-17-18(19(24)16-10-13(2)9-14(3)11-16)23(21(26)22-20(17)25)12-15-7-5-6-8-15/h5-6,9-11,15H,4,7-8,12H2,1-3H3,(H,22,25,26)

SMILES Code: O=C1NC(C(CC)=C(C(C2=CC(C)=CC(C)=C2)=O)N1CC3CC=CC3)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 352.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Wamberg M, Pedersen EB, El-Brollosy NR, Nielsen C. Synthesis of 6-arylvinyl analogues of the HIV drugs SJ-3366 and Emivirine. Bioorg Med Chem. 2004 Mar 1;12(5):1141-9. PubMed PMID: 14980626.

2: Baba M. SJ-3366 Sam Jin Pharmaceutical. Curr Opin Investig Drugs. 2002 Aug;3(8):1146-8. Review. PubMed PMID: 12211405.

3: Buckheit RW Jr, Watson K, Fliakas-Boltz V, Russell J, Loftus TL, Osterling MC, Turpin JA, Pallansch LA, White EL, Lee JW, Lee SH, Oh JW, Kwon HS, Chung SG, Cho EH. SJ-3366, a unique and highly potent nonnucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1 (HIV-1) that also inhibits HIV-2. Antimicrob Agents Chemother. 2001 Feb;45(2):393-400. PubMed PMID: 11158731; PubMed Central PMCID: PMC90303.