Lofepramine hydrochloride

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H581257

CAS#: 26786-32-3(HCl)

Description: Lofepramine is an antidepressant; serotonin and norepinephrine re-uptake inhibitor (SNRI). A psychotropic IMIPRAMINE derivative that acts as a tricyclic antidepressant and possesses few anticholinergic properties. It is metabolized to DESIPRAMINE. Lofepramine is a third generation tricyclic antidepressant utilized throughout Europe and Japan for the treatment of major depression.


Chemical Structure

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Lofepramine hydrochloride
CAS# 26786-32-3(HCl)

Theoretical Analysis

Hodoodo Cat#: H581257
Name: Lofepramine hydrochloride
CAS#: 26786-32-3(HCl)
Chemical Formula: C26H28Cl2N2O
Exact Mass: 454.16
Molecular Weight: 455.423
Elemental Analysis: C, 68.57; H, 6.20; Cl, 15.57; N, 6.15; O, 3.51

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 26786-32-3(HCl)   23047-25-8  

Synonym: Lofepramine hydrochloride; DB-2182; WHR 2908A; WHR-2908A;

IUPAC/Chemical Name: 4'-Chloro-2-((3-(10,11-dihydro-5H-dibenz(b,f)azepin-5-yl)propyl)methylamino)acetophenone monohydrochloride

InChi Key: ZWZIQPOLMDPIQM-UHFFFAOYSA-N

InChi Code: InChI=1S/C26H27ClN2O.ClH/c1-28(19-26(30)22-13-15-23(27)16-14-22)17-6-18-29-24-9-4-2-7-20(24)11-12-21-8-3-5-10-25(21)29;/h2-5,7-10,13-16H,6,11-12,17-19H2,1H3;1H

SMILES Code: O=C(C1=CC=C(Cl)C=C1)CN(CCCN2C3=CC=CC=C3CCC4=CC=CC=C42)C.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 455.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Lancaster SG, Gonzalez JP. Lofepramine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness. Drugs. 1989 Feb;37(2):123-40. Review. PubMed PMID: 2649353.

2: Herdman JR, Cowen PJ, Campling GM, Hockney RA, Laver D, Sharpley AL. Effect of lofepramine on 5-HT function and sleep. J Affect Disord. 1993 Sep;29(1):63-72. PubMed PMID: 8254146.

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4: Hopes H. Effects of lofepramine on human sleep: a pilot study. Int Clin Psychopharmacol. 1989 Oct;4(4):295-300. PubMed PMID: 2607127.

5: Ghose K, Spragg BP. Pharmacokinetics of lofepramine and amitriptyline in elderly healthy subjects. Int Clin Psychopharmacol. 1989 Jul;4(3):201-15. PubMed PMID: 2677125.

6: Marneros A, Philipp M. A double-blind trial with amitriptyline and lofepramine in the treatment of endogenous depression. Int Pharmacopsychiatry. 1979;14(5):300-4. PubMed PMID: 395129.

7: Leonard BE. A comparison of the pharmacological properties of the novel tricyclic antidepressant lofepramine with its major metabolite, desipramine: a review. Int Clin Psychopharmacol. 1987 Oct;2(4):281-97. Review. PubMed PMID: 2891742.

8: Strandgården K, Gunnarsson PO. Metabolism of lofepramine and imipramine in liver microsomes from rat and man. Xenobiotica. 1994 Aug;24(8):703-11. PubMed PMID: 7839694.

9: Elm T, Hansen EL. Simultaneous determination of lofepramine and desipramine by a high-performance liquid chromatographic method used for therapeutic drug monitoring. J Chromatogr B Biomed Appl. 1995 Mar 24;665(2):355-61. PubMed PMID: 7795815.

10: Tan RS, Barlow RJ, Abel C, Reddy S, Palmer AJ, Fletcher AE, Nicholl CG, Pitt BM, Bulpitt CJ. The effect of low dose lofepramine in depressed elderly patients in general medical wards. Br J Clin Pharmacol. 1994 Apr;37(4):321-4. PubMed PMID: 8018452; PubMed Central PMCID: PMC1364731.

11: Darcy P, Kelly JP, Leonard BE, Henry JA. The effect of lofepramine and other related agents on the motility of Tetrahymena pyriformis. Toxicol Lett. 2002 Mar 10;128(1-3):207-14. PubMed PMID: 11869831.

12: Reid F, Henry JA. Lofepramine overdosage. Pharmacopsychiatry. 1990 Jan;23 Suppl 1:23-7. Review. PubMed PMID: 2408087.

13: Ghose K, Sedman E. A double-blind comparison of the pharmacodynamic effects of single doses of lofepramine, amitriptyline and placebo in elderly subjects. Eur J Clin Pharmacol. 1987;33(5):505-9. PubMed PMID: 3428344.

14: Lofepramine: a return to tricyclic antidepressives. Drug Ther Bull. 1983 Dec 16;21(25):99-100. PubMed PMID: 6662044.

15: Kelly JP, Leonard BE. An investigation of the antidepressant properties of lofepramine and its desmethylated metabolites in the forced swim and olfactory bulbectomized rat models of depression. Eur Neuropsychopharmacol. 1999 Jan;9(1-2):101-5. PubMed PMID: 10082234.

16: Pitt BM. Lofepramine in the elderly. Int Clin Psychopharmacol. 1988 Nov;3 Suppl 2:49-54. Review. PubMed PMID: 3063744.

17: Puri BK, Bydder GM, Chaudhuri KR, Al Saffar BY, Curati WL, White SJ, Mitchell L, Hajnal JV, Horrobin DF. MRI changes in multiple sclerosis following treatment with lofepramine and L-phenylalanine. Neuroreport. 2001 Jul 3;12(9):1821-4. PubMed PMID: 11435905.

18: Pugh R, Bell J, Cooper AJ, Dunstan S, Greedharry D, Pomeroy J, Raptopoulos P, Rowsell C, Steinert J, Priest RG. Does lofepramine have fewer side effects than amitriptyline? Results of a comparative trial. J Affect Disord. 1982 Dec;4(4):355-63. PubMed PMID: 6219149.

19: Mariategui J, Chávez H, Olivares A. [Lofepramine: a comparative clinical study with amitriptyline]. Acta Physiol Lat Am. 1978 Sep;24(3):201-9. Spanish. PubMed PMID: 375679.

20: Kelly C, Roche S, Naguib M, Webb S, Roberts M, Pitt B. A prospective evaluation of the hepatotoxicity of lofepramine in the elderly. Int Clin Psychopharmacol. 1993 Summer;8(2):83-6. PubMed PMID: 8102151.