WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H562992
CAS#: 222716-34-9
Description: SZL-P1-41 is a Skp2 inhibitor. It acts by selectively suppressing Skp2 SCF E3 ligase activity.
Hodoodo Cat#: H562992
Name: SZL-P1-41
CAS#: 222716-34-9
Chemical Formula: C24H24N2O3S
Exact Mass: 420.15
Molecular Weight: 420.520
Elemental Analysis: C, 68.55; H, 5.75; N, 6.66; O, 11.41; S, 7.62
Synonym: SZL-P1-41; SZL P1 41; SZLP141; SKP2 E3 Ligase Inhibitor III; SZLP-141; SZLP 141;
IUPAC/Chemical Name: 3-(2-Benzothiazolyl)-6-ethyl-7-hydroxy-8-(1-piperidinylmethyl)-4H-1-benzopyran-4-one
InChi Key: JKIXLEKBXHMXTN-UHFFFAOYSA-N
InChi Code: InChI=1S/C24H24N2O3S/c1-2-15-12-16-22(28)18(24-25-19-8-4-5-9-20(19)30-24)14-29-23(16)17(21(15)27)13-26-10-6-3-7-11-26/h4-5,8-9,12,14,27H,2-3,6-7,10-11,13H2,1H3
SMILES Code: O=C1C(C2=NC3=CC=CC=C3S2)=COC4=C(CN5CCCCC5)C(O)=C(CC)C=C14
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 420.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Mikamo M, Kitagawa K, Sakai S, Uchida C, Ohhata T, Nishimoto K, Niida H, Suzuki S, Nakayama KI, Inui N, Suda T, Kitagawa M. Inhibiting Skp2 E3 Ligase Suppresses Bleomycin-Induced Pulmonary Fibrosis. Int J Mol Sci. 2018 Feb 6;19(2). pii: E474. doi: 10.3390/ijms19020474. PubMed PMID: 29415439; PubMed Central PMCID: PMC5855696.