WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H562996
CAS#: 1519043-97-0
Description: YCW-E11 is a inhibitor of antiapoptotic Bcl-2 family proteins.
Hodoodo Cat#: H562996
Name: YCW-E11
CAS#: 1519043-97-0
Chemical Formula: C21H19ClN4
Exact Mass: 362.13
Molecular Weight: 362.860
Elemental Analysis: C, 69.51; H, 5.28; Cl, 9.77; N, 15.44
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Synonym: YCW-E11; YCW E11; YCWE11;
IUPAC/Chemical Name: N-(2-(3-(3,5-dichlorophenyl)ureido)ethyl)-3-(2-(3,4-dihydroxyphenoxy)phenyl)thiophene-2-sulfonamide
InChi Key: YCTPOOSUMJYWMU-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H18N4.ClH/c1-25(2)20-14-19(16-9-11-22-12-10-16)21(24-23-20)18-8-7-15-5-3-4-6-17(15)13-18;/h3-14H,1-2H3;1H
SMILES Code: CN(C)C1=NN=C(C2=CC(C=CC=C3)=C3C=C2)C(C4=CC=NC=C4)=C1.Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 362.86 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Yang C, Chen S, Zhou M, Li Y, Li Y, Zhang Z, Liu Z, Ba Q, Li J, Wang H, Yan X, Ma D, Wang R. Development of 3-phenyl-N-(2-(3-phenylureido)ethyl)-thiophene-2-sulfonamide compounds as inhibitors of antiapoptotic Bcl-2 family proteins. ChemMedChem. 2014 Jul;9(7):1436-52. doi: 10.1002/cmdc.201400058. Epub 2014 Apr 29. PubMed PMID: 24782462.