Carvacrol
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    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H558124

CAS#: 499-75-2

Description: Carvacrol is an TRPM7 inhibitor and a monoterpenic phenol produced by an abundant number of aromatic plants.


Chemical Structure

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Carvacrol
CAS# 499-75-2

Theoretical Analysis

Hodoodo Cat#: H558124
Name: Carvacrol
CAS#: 499-75-2
Chemical Formula: C10H14O
Exact Mass: 150.10
Molecular Weight: 150.220
Elemental Analysis: C, 79.96; H, 9.39; O, 10.65

Price and Availability

Size Price Availability Quantity
25g USD 250 2 Weeks
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Synonym: Antioxine; Carvacrol; BRN-1860514; BRN 1860514; BRN1860514; Karvakrol;

IUPAC/Chemical Name: Phenol, 2-methyl-5-(1-methylethyl)-

InChi Key: RECUKUPTGUEGMW-UHFFFAOYSA-N

InChi Code: InChI=1S/C10H14O/c1-7(2)9-5-4-8(3)10(11)6-9/h4-7,11H,1-3H3

SMILES Code: OC1=CC(C(C)C)=CC=C1C

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 150.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Fan K, Li X, Cao Y, Qi H, Li L, Zhang Q, Sun H. Carvacrol inhibits proliferation and induces apoptosis in human colon cancer cells. Anticancer Drugs. 2015 Sep;26(8):813-23. doi: 10.1097/CAD.0000000000000263. PubMed PMID: 26214321.

2: Chen W, Xu B, Xiao A, Liu L, Fang X, Liu R, Turlova E, Barszczyk A, Zhong X, Sun CL, Britto LR, Feng ZP, Sun HS. TRPM7 inhibitor carvacrol protects brain from neonatal hypoxic-ischemic injury. Mol Brain. 2015 Feb 19;8:11. doi: 10.1186/s13041-015-0102-5. PubMed PMID: 25761704; PubMed Central PMCID: PMC4337201.

3: Suntres ZE, Coccimiglio J, Alipour M. The bioactivity and toxicological actions of carvacrol. Crit Rev Food Sci Nutr. 2015;55(3):304-18. doi: 10.1080/10408398.2011.653458. Review. PubMed PMID: 24915411.

4: Cacciatore I, Di Giulio M, Fornasari E, Di Stefano A, Cerasa LS, Marinelli L, Turkez H, Di Campli E, Di Bartolomeo S, Robuffo I, Cellini L. Carvacrol codrugs: a new approach in the antimicrobial plan. PLoS One. 2015 Apr 10;10(4):e0120937. doi: 10.1371/journal.pone.0120937. eCollection 2015. PubMed PMID: 25859852; PubMed Central PMCID: PMC4393269.

5: Chaillot J, Tebbji F, Remmal A, Boone C, Brown GW, Bellaoui M, Sellam A. The Monoterpene Carvacrol Generates Endoplasmic Reticulum Stress in the Pathogenic Fungus Candida albicans. Antimicrob Agents Chemother. 2015 Aug;59(8):4584-92. doi: 10.1128/AAC.00551-15. Epub 2015 May 26. PubMed PMID: 26014932; PubMed Central PMCID: PMC4505245.

6: Sánchez C, Aznar R, Sánchez G. The effect of carvacrol on enteric viruses. Int J Food Microbiol. 2015 Jan 2;192:72-6. doi: 10.1016/j.ijfoodmicro.2014.09.028. Epub 2014 Oct 11. PubMed PMID: 25310265.

7: Joca HC, Vieira DC, Vasconcelos AP, Araújo DA, Cruz JS. Carvacrol modulates voltage-gated sodium channels kinetics in dorsal root ganglia. Eur J Pharmacol. 2015 Jun 5;756:22-9. doi: 10.1016/j.ejphar.2015.03.007. Epub 2015 Mar 17. PubMed PMID: 25794844.

8: Pastor J, García M, Steinbauer S, Setzer WN, Scull R, Gille L, Monzote L. Combinations of ascaridole, carvacrol, and caryophyllene oxide against Leishmania. Acta Trop. 2015 May;145:31-8. doi: 10.1016/j.actatropica.2015.02.002. Epub 2015 Feb 17. PubMed PMID: 25697866.

9: Chen WL, Barszczyk A, Turlova E, Deurloo M, Liu B, Yang BB, Rutka JT, Feng ZP, Sun HS. Inhibition of TRPM7 by carvacrol suppresses glioblastoma cell proliferation, migration and invasion. Oncotarget. 2015 Jun 30;6(18):16321-40. PubMed PMID: 25965832; PubMed Central PMCID: PMC4599272.

10: Lee KP, Sudjarwo GW, Jung SH, Lee D, Lee DY, Lee GB, Baek S, Kim DY, Lee HM, Kim B, Kwon SC, Won KJ. Carvacrol inhibits atherosclerotic neointima formation by downregulating reactive oxygen species production in vascular smooth muscle cells. Atherosclerosis. 2015 Jun;240(2):367-73. doi: 10.1016/j.atherosclerosis.2015.03.038. Epub 2015 Mar 28. PubMed PMID: 25875388.

11: Tabari MA, Youssefi MR, Barimani A, Araghi A. Carvacrol as a potent natural acaricide against Dermanyssus gallinae. Parasitol Res. 2015 Oct;114(10):3801-6. doi: 10.1007/s00436-015-4610-0. Epub 2015 Jul 7. PubMed PMID: 26143865.

12: Shaaban HA, Edris AE. Factors affecting the phase behavior and antimicrobial activity of carvacrol microemulsions. J Oleo Sci. 2015;64(4):393-404. doi: 10.5650/jos.ess14194. Epub 2015 Mar 11. PubMed PMID: 25766929.

13: Nair DV, Kiess A, Nannapaneni R, Schilling W, Sharma CS. The combined efficacy of carvacrol and modified atmosphere packaging on the survival of Salmonella, Campylobacter jejuni and lactic acid bacteria on turkey breast cutlets. Food Microbiol. 2015 Aug;49:134-41. doi: 10.1016/j.fm.2015.01.010. Epub 2015 Feb 7. PubMed PMID: 25846923.

14: Trailović SM, Marjanović DS, Nedeljković Trailović J, Robertson AP, Martin RJ. Interaction of carvacrol with the Ascaris suum nicotinic acetylcholine receptors and gamma-aminobutyric acid receptors, potential mechanism of antinematodal action. Parasitol Res. 2015 Aug;114(8):3059-68. doi: 10.1007/s00436-015-4508-x. Epub 2015 May 7. PubMed PMID: 25944741; PubMed Central PMCID: PMC4607277.

15: Jesus FP, Ferreiro L, Bizzi KS, Loreto ÉS, Pilotto MB, Ludwig A, Alves SH, Zanette RA, Santurio JM. In vitro activity of carvacrol and thymol combined with antifungals or antibacterials against Pythium insidiosum. J Mycol Med. 2015 Jun;25(2):e89-93. doi: 10.1016/j.mycmed.2014.10.023. Epub 2014 Nov 13. PubMed PMID: 25639921.

16: Maryam K, Shakeri S, Kiani K. Preparation and in vitro investigation of antigastric cancer activities of carvacrol-loaded human serum albumin nanoparticles. IET Nanobiotechnol. 2015 Oct;9(5):294-9. doi: 10.1049/iet-nbt.2014.0040. PubMed PMID: 26435283.

17: Yuan G, Lv H, Yang B, Chen X, Sun H. Physical Properties, Antioxidant and Antimicrobial Activity of Chitosan Films Containing Carvacrol and Pomegranate Peel Extract. Molecules. 2015 Jun 15;20(6):11034-45. doi: 10.3390/molecules200611034. PubMed PMID: 26083037.

18: Li WT, Zhang SY, Zhou YF, Zhang BF, Liang ZQ, Liu YH, Wei Y, Li CK, Meng XJ, Xia M, Dan Y, Song JN. Carvacrol attenuates traumatic neuronal injury through store-operated Ca(2+) entry-independent regulation of intracellular Ca(2+) homeostasis. Neurochem Int. 2015 Nov;90:107-13. doi: 10.1016/j.neuint.2015.07.020. Epub 2015 Jul 26. PubMed PMID: 26220904.

19: Ciandrini E, Campana R, Federici S, Manti A, Battistelli M, Falcieri E, Papa S, Baffone W. In vitro activity of Carvacrol against titanium-adherent oral biofilms and planktonic cultures. Clin Oral Investig. 2014 Nov;18(8):2001-13. doi: 10.1007/s00784-013-1179-9. Epub 2014 Jan 24. PubMed PMID: 24458367.

20: Novato TP, Araújo LX, de Monteiro CM, Maturano R, Senra Tde O, da Silva Matos R, Gomes GA, de Carvalho MG, Daemon E. Evaluation of the combined effect of thymol, carvacrol and (E)-cinnamaldehyde on Amblyomma sculptum (Acari: Ixodidae) and Dermacentor nitens (Acari: Ixodidae) larvae. Vet Parasitol. 2015 Sep 15;212(3-4):331-5. doi: 10.1016/j.vetpar.2015.08.021. Epub 2015 Aug 24. PubMed PMID: 26346899.