WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H596960
CAS#: 69839-80-1
Description: L-Chlorozotocin is a glucose-linked chloroethylnitrosourea with potential antineoplastic activity. Chlorozotocin alkylates DNA and proteins, induces the formation of interstrand DNA and DNA-protein crosslinks, and causes DNA strand breakage, thereby damaging DNA and resulting in cell death. This agent has been shown to exhibit antitumor and immunomodulatory effects in cell lines and animal models. Chlorozotocin is a mutagen and is less myelotoxic than other nitrosoureas.
Hodoodo Cat#: H596960
Name: L-Chlorozotocin
CAS#: 69839-80-1
Chemical Formula: C9H16ClN3O7
Exact Mass: 313.07
Molecular Weight: 313.690
Elemental Analysis: C, 34.46; H, 5.14; Cl, 11.30; N, 13.40; O, 35.70
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Synonym: L-Chlorozotocin; NSC 291322; NSC-291322; NSC291322;
IUPAC/Chemical Name: 1-(2-chloroethyl)-1-nitroso-3-((2R,3R,4S,5R)-3,4,5,6-tetrahydroxy-1-oxohexan-2-yl)urea
InChi Key: MKQWTWSXVILIKJ-LXGUWJNJSA-N
InChi Code: InChI=1S/C9H16ClN3O7/c10-1-2-13(12-20)9(19)11-5(3-14)7(17)8(18)6(16)4-15/h3,5-8,15-18H,1-2,4H2,(H,11,19)/t5-,6+,7+,8+/m0/s1
SMILES Code: O=C[C@H](NC(N(CCCl)N=O)=O)[C@H]([C@@H]([C@@H](CO)O)O)O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 313.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Johnston TP, McCaleb GS, Anderson T, Murinson DS. L-Chlorozotocin. J Med Chem. 1979 May;22(5):597-9. PubMed PMID: 156793.