WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H563028
CAS#: 1268264-10-3
Description: SOMG-833 HCl is a selective c-MET inhibitor that acts by blocking c-MET dependent neoplastic effects and exerting antitumor activity.
Hodoodo Cat#: H563028
Name: SOMG-833 HCl
CAS#: 1268264-10-3
Chemical Formula: C22H23ClF3N5O2
Exact Mass: 481.15
Molecular Weight: 481.900
Elemental Analysis: C, 54.83; H, 4.81; Cl, 7.36; F, 11.83; N, 14.53; O, 6.64
Synonym: SOMG-833 HCl; SOMG 833 HCl; SOMG833 HCl; SOMG-833 Hydrochloride; SOMG833 Hydrochloride; SOMG 833 Hydrochloride; Zgwatinib Hydrochloride; Zgwatinib HCl;
IUPAC/Chemical Name: [3-(4-Methyl-piperazin-1-yl)-7-trifluoromethyl-quinolin-5-yl]-(3-nitro-benzyl)-amine Hydrochloride
InChi Key: GVCODABMZBTSTD-UHFFFAOYSA-N
InChi Code: InChI=1S/C22H22F3N5O2.ClH/c1-28-5-7-29(8-6-28)18-12-19-20(10-16(22(23,24)25)11-21(19)27-14-18)26-13-15-3-2-4-17(9-15)30(31)32;/h2-4,9-12,14,26H,5-8,13H2,1H3;1H
SMILES Code: O=[N+](C1=CC(CNC2=C3C=C(N4CCN(C)CC4)C=NC3=CC(C(F)(F)F)=C2)=CC=C1)[O-].[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 481.90 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Zhang HT, Wang L, Ai J, Chen Y, He CX, Ji YC, Huang M, Yang JY, Zhang A, Ding J, Geng MY. SOMG-833, a novel selective c-MET inhibitor, blocks c-MET-dependent neoplastic effects and exerts antitumor activity. J Pharmacol Exp Ther. 2014 Jul;350(1):36-45. doi: 10.1124/jpet.114.214817. Epub 2014 Apr 16. PubMed PMID: 24741075.