WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H563029
CAS#: 1374006-96-8
Description: ERDRP-0519 is an orally available polymerase inhibitor. It shows efficacy against a lethal morbillivirus infection in a large animal model.
Hodoodo Cat#: H563029
Name: ERDRP-0519
CAS#: 1374006-96-8
Chemical Formula: C23H30F3N5O4S
Exact Mass: 529.20
Molecular Weight: 529.570
Elemental Analysis: C, 52.16; H, 5.71; F, 10.76; N, 13.22; O, 12.08; S, 6.05
Synonym: ERDRP-0519; ERDRP 0519; ERDRP0519;
IUPAC/Chemical Name: 1-Methyl-N-[4-[[(2S)-2-[2-(4-morpholinyl)ethyl]-1-piperidinyl]sulfonyl]phenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide
InChi Key: JVZHTUQIMBYDSX-SFHVURJKSA-N
InChi Code: InChI=1S/C23H30F3N5O4S/c1-29-20(16-21(28-29)23(24,25)26)22(32)27-17-5-7-19(8-6-17)36(33,34)31-10-3-2-4-18(31)9-11-30-12-14-35-15-13-30/h5-8,16,18H,2-4,9-15H2,1H3,(H,27,32)/t18-/m0/s1
SMILES Code: O=C(C1=CC(C(F)(F)F)=NN1C)NC2=CC=C(S(=O)(N3[C@H](CCN4CCOCC4)CCCC3)=O)C=C2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 529.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Krumm SA, Yan D, Hovingh ES, Evers TJ, Enkirch T, Reddy GP, Sun A, Saindane MT, Arrendale RF, Painter G, Liotta DC, Natchus MG, von Messling V, Plemper RK. An orally available, small-molecule polymerase inhibitor shows efficacy against a lethal morbillivirus infection in a large animal model. Sci Transl Med. 2014 Apr 16;6(232):232ra52. doi: 10.1126/scitranslmed.3008517. PubMed PMID: 24739760; PubMed Central PMCID: PMC4080709.