WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H591577
CAS#: 90-47-1
Description: Xanthone was introduced as an insecticide and it currently finds uses as ovicide for codling moth eggs and as a larvicide. Xanthone is also used in the preparation of xanthydrol, which is used in the determination of urea levels in the blood.
Hodoodo Cat#: H591577
Name: Xanthone
CAS#: 90-47-1
Chemical Formula: C13H8O2
Exact Mass: 196.05
Molecular Weight: 196.210
Elemental Analysis: C, 79.58; H, 4.11; O, 16.31
Synonym: Xanthone; NSC 14978; NSC-14978; NSC14978
IUPAC/Chemical Name: 9H-Xanthen-9-one
InChi Key: JNELGWHKGNBSMD-UHFFFAOYSA-N
InChi Code: InChI=1S/C13H8O2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1-8H
SMILES Code: O=C1C2=C(OC3=C1C=CC=C3)C=CC=C2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 196.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
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5: Castillo-Arellano JI, Guzmán-Gutiérrez SL, Ibarra-Sánchez A, Hernández-Ortega S, Nieto-Camacho A, Medina-Campos ON, Pedraza-Chaverri J, Reyes-Chilpa R, González-Espinosa C. Jacareubin inhibits FcεRI-induced extracellular calcium entry and production of reactive oxygen species required for anaphylactic degranulation of mast cells. Biochem Pharmacol. 2018 May 24;154:344-356. doi: 10.1016/j.bcp.2018.05.002. [Epub ahead of print] PubMed PMID: 29802828.
6: Ibrahim SRM, El-Agamy DS, Abdallah HM, Ahmed N, Elkablawy MA, Mohamed GA. Protective activity of tovophyllin A, a xanthone isolated from Garcinia mangostana pericarps, against acetaminophen-induced liver damage: role of Nrf2 activation. Food Funct. 2018 May 23. doi: 10.1039/c8fo00378e. [Epub ahead of print] PubMed PMID: 29790527.
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8: Ding SM, Lan T, Ye GJ, Huang JJ, Hu Y, Zhu YR, Wang B. Novel oxazolxanthone derivatives as a new type of α-glucosidase inhibitor: synthesis, activities, inhibitory modes and synergetic effect. Bioorg Med Chem. 2018 May 15. pii: S0968-0896(18)30583-2. doi: 10.1016/j.bmc.2018.05.008. [Epub ahead of print] PubMed PMID: 29776833.
9: Lee D, Kim YM, Jung K, Chin YW, Kang KS. Alpha-Mangostin Improves Insulin Secretion and Protects INS-1 Cells from Streptozotocin-Induced Damage. Int J Mol Sci. 2018 May 16;19(5). pii: E1484. doi: 10.3390/ijms19051484. PubMed PMID: 29772703; PubMed Central PMCID: PMC5983655.
10: Timsina B, Kindlmann P, Rokaya MB, Vrchotová N, Tříska J, Horník Š, Sýkora J. Xanthones Content in Swertia multicaulis D. Don from Nepal. Molecules. 2018 May 3;23(5). pii: E1067. doi: 10.3390/molecules23051067. PubMed PMID: 29751500.
11: Dai Y, Ma F, Shen Y, Xie T, Gao S. Convergent Synthesis of Kibdelone C. Org Lett. 2018 May 18;20(10):2872-2875. doi: 10.1021/acs.orglett.8b00901. Epub 2018 May 8. PubMed PMID: 29738256.
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13: Neves AR, Correia-da-Silva M, Silva PMA, Ribeiro D, Sousa E, Bousbaa H, Pinto M. Synthesis of New Glycosylated Flavonoids with Inhibitory Activity on Cell Growth. Molecules. 2018 May 5;23(5). pii: E1093. doi: 10.3390/molecules23051093. PubMed PMID: 29734739.
14: Yang SQ, Li XM, Xu GM, Li X, An CY, Wang BG. Antibacterial anthraquinone derivatives isolated from a mangrove-derived endophytic fungus Aspergillus nidulans by ethanol stress strategy. J Antibiot (Tokyo). 2018 May 1. doi: 10.1038/s41429-018-0063-x. [Epub ahead of print] PubMed PMID: 29717199.
15: Rocha LW, Bonet IJM, Tambeli CH, de-Faria FM, Parada CA. Local administration of mangiferin prevents experimental inflammatory mechanical hyperalgesia through CINC-1/epinephrine/PKA pathway and TNF-α inhibition. Eur J Pharmacol. 2018 Jul 5;830:87-94. doi: 10.1016/j.ejphar.2018.04.030. Epub 2018 Apr 30. PubMed PMID: 29715452.
16: Kubacka M, Szkaradek N, Mogilski S, Pańczyk K, Siwek A, Gryboś A, Filipek B, Żmudzki P, Marona H, Waszkielewicz AM. Design, synthesis and cardiovascular evaluation of some aminoisopropanoloxy derivatives of xanthone. Bioorg Med Chem. 2018 Apr 18. pii: S0968-0896(17)32186-7. doi: 10.1016/j.bmc.2018.04.038. [Epub ahead of print] PubMed PMID: 29706529.
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18: Zhu L, Liu X, Li D, Sun S, Wang Y, Sun X. Autophagy is a pro-survival mechanism in ovarian cancer against the apoptotic effects of euxanthone. Biomed Pharmacother. 2018 Jul;103:708-718. doi: 10.1016/j.biopha.2018.04.090. Epub 2018 Apr 24. PubMed PMID: 29680739.
19: Khurana RK, Gaspar BL, Welsby G, Katare OP, Singh KK, Singh B. Improving the biopharmaceutical attributes of mangiferin using vitamin E-TPGS co-loaded self-assembled phosholipidic nano-mixed micellar systems. Drug Deliv Transl Res. 2018 Jun;8(3):617-632. doi: 10.1007/s13346-018-0498-4. PubMed PMID: 29637488; PubMed Central PMCID: PMC5937873.
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