WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H558171
CAS#: 99624-27-8
Description: Kazinol B is a natural isoprenylated flavan and stimulates the gene expression and secretion of adiponectin, which is associated with a low risk of types 1 and 2 diabetes mellitus.
Hodoodo Cat#: H558171
Name: Kazinol B
CAS#: 99624-27-8
Chemical Formula: C30H36O4
Exact Mass: 460.26
Molecular Weight: 460.610
Elemental Analysis: C, 78.23; H, 7.88; O, 13.89
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: Kazinol B;
IUPAC/Chemical Name: 5-((S)-6-(1,1-Dimethyl-allyl)-7-hydroxy-1-benzopyran-2-yl)-3-((E)-3-methyl-but-2-enyl)-4-(3-methyl-but-2-enyl)-benzene-1,2-diol
InChi Key: GGWMAHDWGWYVDR-UHFFFAOYSA-N
InChi Code: InChI=1S/C30H36O4/c1-8-30(6,7)24-15-20-11-14-27(34-28(20)17-25(24)31)23-16-26(32)29(33)22(13-10-19(4)5)21(23)12-9-18(2)3/h8-11,14,16-17,31-33H,1,12-13,15H2,2-7H3
SMILES Code: OC1=CC(C2=CC=C3C(O2)=CC(O)=C(C(C)(C)C=C)C3)=C(C/C=C(C)\C)C(C/C=C(C)\C)=C1O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 460.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Lee H, Li H, Jeong JH, Noh M, Ryu JH. Kazinol B from Broussonetia kazinoki improves insulin sensitivity via Akt and AMPK activation in 3T3-L1 adipocytes. Fitoterapia. 2016 Jul;112:90-6. doi: 10.1016/j.fitote.2016.05.006. Epub 2016 May
17. PubMed PMID: 27223849.
2: Ryu JH, Ahn H, Jin Lee H. Inhibition of nitric oxide production on LPS-activated macrophages by kazinol B from Broussonetia kazinoki. Fitoterapia. 2003 Jun;74(4):350-4. PubMed PMID: 12781805.
3: Wang JP, Tsao LT, Raung SL, Lin CN. The signal transduction mechanism involved in kazinol B-stimulated superoxide anion generation in rat neutrophils. Br J Pharmacol. 1998 Oct;125(3):517-25. PubMed PMID: 9806335; PubMed Central PMCID: PMC1565651.
4: Wang JP, Hsu MF, Ko HH, Lin CN. Stimulation of cellular free Ca2+ elevation and inhibition of store-operated Ca2+ entry by kazinol B in neutrophils. Naunyn Schmiedebergs Arch Pharmacol. 2004 Dec;370(6):500-9. Epub 2004 Nov 19. PubMed PMID: 15558242.
5: Lin CN, Lu CM, Lin HC, Fang SC, Shieh BJ, Hsu MF, Wang JP, Ko FN, Teng CM. Novel antiplatelet constituents from formosan moraceous plants. J Nat Prod. 1996
Sep;59(9):834-8. PubMed PMID: 8864236.
6: Sohn HY, Son KH, Kwon CS, Kwon GS, Kang SS. Antimicrobial and cytotoxic activity of 18 prenylated flavonoids isolated from medicinal plants: Morus alba L., Morus mongolica Schneider, Broussnetia papyrifera (L.) Vent, Sophora flavescens Ait and Echinosophora koreensis Nakai. Phytomedicine. 2004 Nov;11(7-8):666-72. PubMed PMID: 15636183.
7: Chi YS, Jong HG, Son KH, Chang HW, Kang SS, Kim HP. Effects of naturally occurring prenylated flavonoids on enzymes metabolizing arachidonic acid: cyclooxygenases and lipoxygenases. Biochem Pharmacol. 2001 Nov 1;62(9):1185-91. PubMed PMID: 11705451.
8: Park JY, Yuk HJ, Ryu HW, Lim SH, Kim KS, Park KH, Ryu YB, Lee WS. Evaluation of polyphenols from Broussonetia papyrifera as coronavirus protease inhibitors. J Enzyme Inhib Med Chem. 2017 Dec;32(1):504-515. doi: 10.1080/14756366.2016.1265519. PubMed PMID: 28112000.
