WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H563049
CAS#: 418800-15-4
Description: Lenaldekar is a inhibitor of T-cell expansion and autoimmune encephalomyelitis.
Hodoodo Cat#: H563049
Name: Lenaldekar
CAS#: 418800-15-4
Chemical Formula: C18H14N4
Exact Mass: 286.12
Molecular Weight: 286.330
Elemental Analysis: C, 75.50; H, 4.93; N, 19.57
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Synonym: Lenaldekar; LDK;
IUPAC/Chemical Name: 1H-Indole-3-carboxaldehyde 2-(8-quinolinyl)hydrazone
InChi Key: QLMFOQYHZJSYJF-CIAFOILYSA-N
InChi Code: InChI=1S/C18H14N4/c1-2-8-16-15(7-1)14(11-20-16)12-21-22-17-9-3-5-13-6-4-10-19-18(13)17/h1-12,20,22H/b21-12+
SMILES Code: C1(/C=N/NC2=C3N=CC=CC3=CC=C2)=CNC4=C1C=CC=C4
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 286.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Wang X, Cusick MF, Wang Y, Sun P, Libbey JE, Trinkaus K, Fujinami RS, Song SK. Diffusion basis spectrum imaging detects and distinguishes coexisting subclinical inflammation, demyelination and axonal injury in experimental autoimmune encephalomyelitis mice. NMR Biomed. 2014 Jul;27(7):843-52. doi: 10.1002/nbm.3129. Epub 2014 May 12. PubMed PMID: 24816651; PubMed Central PMCID: PMC4071074.
2: Cusick MF, Libbey JE, Trede NS, Fujinami RS. Targeting insulin-like growth factor 1 leads to amelioration of inflammatory demyelinating disease. PLoS One. 2014 Apr 9;9(4):e94486. doi: 10.1371/journal.pone.0094486. eCollection 2014. PubMed PMID: 24718491; PubMed Central PMCID: PMC3981810.
3: Clements WK, Traver D. Fish pharming: zebrafish antileukemia screening. Blood. 2012 Jun 14;119(24):5614-5. doi: 10.1182/blood-2012-04-425249. PubMed PMID: 22700692.
4: Ridges S, Heaton WL, Joshi D, Choi H, Eiring A, Batchelor L, Choudhry P, Manos EJ, Sofla H, Sanati A, Welborn S, Agarwal A, Spangrude GJ, Miles RR, Cox JE, Frazer JK, Deininger M, Balan K, Sigman M, Müschen M, Perova T, Johnson R, Montpellier B, Guidos CJ, Jones DA, Trede NS. Zebrafish screen identifies novel compound with selective toxicity against leukemia. Blood. 2012 Jun 14;119(24):5621-31. doi: 10.1182/blood-2011-12-398818. Epub 2012 Apr 9. PubMed PMID: 22490804; PubMed Central PMCID: PMC3382926.
5: Cusick MF, Libbey JE, Trede NS, Eckels DD, Fujinami RS. Human T cell expansion and experimental autoimmune encephalomyelitis inhibited by Lenaldekar, a small molecule discovered in a zebrafish screen. J Neuroimmunol. 2012 Mar;244(1-2):35-44. doi: 10.1016/j.jneuroim.2011.12.024. Epub 2012 Jan 14. PubMed PMID: 22245285.