Lenaldekar

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H563049

CAS#: 418800-15-4

Description: Lenaldekar is a inhibitor of T-cell expansion and autoimmune encephalomyelitis.


Chemical Structure

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Lenaldekar
CAS# 418800-15-4

Theoretical Analysis

Hodoodo Cat#: H563049
Name: Lenaldekar
CAS#: 418800-15-4
Chemical Formula: C18H14N4
Exact Mass: 286.12
Molecular Weight: 286.330
Elemental Analysis: C, 75.50; H, 4.93; N, 19.57

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Lenaldekar; LDK;

IUPAC/Chemical Name: 1H-Indole-3-carboxaldehyde 2-(8-quinolinyl)hydrazone

InChi Key: QLMFOQYHZJSYJF-CIAFOILYSA-N

InChi Code: InChI=1S/C18H14N4/c1-2-8-16-15(7-1)14(11-20-16)12-21-22-17-9-3-5-13-6-4-10-19-18(13)17/h1-12,20,22H/b21-12+

SMILES Code: C1(/C=N/NC2=C3N=CC=CC3=CC=C2)=CNC4=C1C=CC=C4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 286.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Wang X, Cusick MF, Wang Y, Sun P, Libbey JE, Trinkaus K, Fujinami RS, Song SK. Diffusion basis spectrum imaging detects and distinguishes coexisting subclinical inflammation, demyelination and axonal injury in experimental autoimmune encephalomyelitis mice. NMR Biomed. 2014 Jul;27(7):843-52. doi: 10.1002/nbm.3129. Epub 2014 May 12. PubMed PMID: 24816651; PubMed Central PMCID: PMC4071074.

2: Cusick MF, Libbey JE, Trede NS, Fujinami RS. Targeting insulin-like growth factor 1 leads to amelioration of inflammatory demyelinating disease. PLoS One. 2014 Apr 9;9(4):e94486. doi: 10.1371/journal.pone.0094486. eCollection 2014. PubMed PMID: 24718491; PubMed Central PMCID: PMC3981810.

3: Clements WK, Traver D. Fish pharming: zebrafish antileukemia screening. Blood. 2012 Jun 14;119(24):5614-5. doi: 10.1182/blood-2012-04-425249. PubMed PMID: 22700692.

4: Ridges S, Heaton WL, Joshi D, Choi H, Eiring A, Batchelor L, Choudhry P, Manos EJ, Sofla H, Sanati A, Welborn S, Agarwal A, Spangrude GJ, Miles RR, Cox JE, Frazer JK, Deininger M, Balan K, Sigman M, Müschen M, Perova T, Johnson R, Montpellier B, Guidos CJ, Jones DA, Trede NS. Zebrafish screen identifies novel compound with selective toxicity against leukemia. Blood. 2012 Jun 14;119(24):5621-31. doi: 10.1182/blood-2011-12-398818. Epub 2012 Apr 9. PubMed PMID: 22490804; PubMed Central PMCID: PMC3382926.

5: Cusick MF, Libbey JE, Trede NS, Eckels DD, Fujinami RS. Human T cell expansion and experimental autoimmune encephalomyelitis inhibited by Lenaldekar, a small molecule discovered in a zebrafish screen. J Neuroimmunol. 2012 Mar;244(1-2):35-44. doi: 10.1016/j.jneuroim.2011.12.024. Epub 2012 Jan 14. PubMed PMID: 22245285.