KC 400

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H558189

CAS#: 12737-87-0

Description: KC 400 is a mixture of polychlorinated biphenyls.

Chemical Structure

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KC 400
CAS# 12737-87-0
Instruction

Theoretical Analysis

Hodoodo Cat#: H558189
Name: KC 400
CAS#: 12737-87-0
Chemical Formula: C12H6Cl4
Exact Mass: 289.92
Molecular Weight: 291.980
Elemental Analysis: C, 49.36; H, 2.07; Cl, 48.56

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: KC 400; KC400; KC-400; Kanechlor 400; Kaneclor 400;

IUPAC/Chemical Name: 3,3',5,5'-tetrachloro-1,1'-biphenyl

InChi Key: UTMWFJSRHLYRPY-UHFFFAOYSA-N

InChi Code: InChI=1S/C12H6Cl4/c13-9-1-7(2-10(14)5-9)8-3-11(15)6-12(16)4-8/h1-6H

SMILES Code: ClC1=CC(Cl)=CC(C2=CC(Cl)=CC(Cl)=C2)=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 291.98 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Honda T, Nonaka S, Murayama F, Ohgami T, Shimoyama T, Yoshida H. Effects of KC-400 (polychlorinated biphenyls) on porphyrin metabolism--liver and blood porphyrin analyses in rats treated with KC-400. J Dermatol. 1983 Jun;10(3):259-65. PubMed PMID: 6417210.

2: Nonaka S, Ohgami T, Yamashita K, Yoshida H, Murayama F. [Effects of KC-400 (polychlorinated biphenyls) on porphyrin metabolism. The influence of KC-400 and glutathione on mice fed with a feed containing a 0.1% griseofulvin]. Fukuoka Igaku Zasshi. 1985 May;76(5):215-20. Japanese. PubMed PMID: 3930371.

3: Nakayama K, Sei N, Oshima Y, Tashiro K, Shimasaki Y, Honjo T. Alteration of gene expression profiles in the brain of Japanese medaka (Oryzias latipes) exposed to KC-400 or PCB126. Mar Pollut Bull. 2008;57(6-12):460-6. doi: 10.1016/j.marpolbul.2008.02.020. Epub 2008 Mar 28. PubMed PMID: 18374953.

4: Nishihara Y. Comparative study of the effects of biphenyl and Kanechlor-400 on the respiratory and energy linked activities of rat liver mitochondria. Br J Ind Med. 1985 Feb;42(2):128-32. PubMed PMID: 3918562; PubMed Central PMCID: PMC1007435.

5: Takasuga T, Kumar KS, Noma Y, Sakai S. Chemical characterization of polychlorinated biphenyls, -dibenzo-p-dioxins, and -dibenzofurans in technical Kanechlor PCB formulations in Japan. Arch Environ Contam Toxicol. 2005 Oct;49(3):385-95. Epub 2005 Sep 15. PubMed PMID: 16170452.

6: Nose K, Falandysz J, Wyrzykowska B, Orlikowska A, Noma Y. By-side PCDD/Fs in technical PCB formulations of Kanechlor series. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2009 Dec;44(14):1528-37. doi: 10.1080/10934520903263348. PubMed PMID: 20183510.

7: Hori S, Obana H, Kashimoto T, Otake T, Nishimura H, Ikegami N, Kunita N, Uda H. Effect of polychlorinated biphenyls and polychlorinated quaterphenyls in Cynomolgus monkey (Macaca fascicularis). Toxicology. 1982;24(2):123-39. PubMed PMID: 6814017.

8: Furukawa K, Tomizuka N, Kamibayashi A. Metabolic breakdown of Kaneclors (polychlorobiphenyls) and their products by Acinetobacter sp. Appl Environ Microbiol. 1983 Jul;46(1):140-5. PubMed PMID: 6412627; PubMed Central PMCID: PMC239279.

9: Nakayama K, Sei N, Handoh IC, Shimasaki Y, Honjo T, Oshima Y. Effects of polychlorinated biphenyls on liver function and sexual characteristics in Japanese medaka (Oryzias latipes). Mar Pollut Bull. 2011;63(5-12):366-9. doi: 10.1016/j.marpolbul.2011.01.015. Epub 2011 Feb 5. PubMed PMID: 21300381.

10: Soong DK, Ling YC. Reassessment of PCDD/DFs and Co-PCBs toxicity in contaminated rice-bran oil responsible for the disease "Yu-Cheng". Chemosphere. 1997 Mar-Apr;34(5-7):1579-86. PubMed PMID: 9134689.

11: Nishihara Y. Uncoupling action of polychlorinated biphenyls (Kanechlor-400) on oxidative phosphorylation in rat liver mitochondria. Arch Environ Contam Toxicol. 1984 Mar;13(2):225-9. PubMed PMID: 6426411.

12: Nishizumi M, Higaki Y. [Effect of PCBs on insulin sensitivity in rats]. Fukuoka Igaku Zasshi. 1995 May;86(5):241-6. Japanese. PubMed PMID: 7628815.

13: Baba D, Katayama A. Enhanced anaerobic biodegradation of polychlorinated biphenyls in burnt soil culture. J Biosci Bioeng. 2007 Jul;104(1):62-8. PubMed PMID: 17697985.

14: Takabatake E, Fujita M, Sawa Y. Combined effects of polychlorinated biphenyls and methylmercury on hepatic microsomal monooxygenases and the hepatotoxic action of bromobenzene. J Pharmacobiodyn. 1980 Sep;3(9):463-9. PubMed PMID: 6780680.

15: Hemminki K, Vineis P. Extrapolation of the evidence on teratogenicity of chemicals between humans and experimental animals: chemicals other than drugs. Teratog Carcinog Mutagen. 1985;5(4):251-318. Review. PubMed PMID: 2866606.

16: Nakagawa M, Shimokawa T, Noguchi A, Ishihara N, Kojima S. Effect of clofibrate on cholesterol metabolism in rats treated with polychlorinated biphenyls. Lipids. 1986 Feb;21(2):159-63. PubMed PMID: 3083175.

17: Shoya S, Horiuchi T, Kohanawa M. Pathological changes of experimental polychlorinated biphenyl poisoning in chickens. Natl Inst Anim Health Q (Tokyo). 1979 Summer;19(1-2):53-64. PubMed PMID: 119917.

18: Yoshihara S, Nagata K, Yoshimura H. Different responsiveness of hepatic and pulmonary microsomal mixed function oxidases to phenobarbital-type and 3-methylcholanthrene-type polychlorinated biphenyls in rats. J Pharmacobiodyn. 1983 Dec;6(12):954-62. PubMed PMID: 6425489.

19: Nagayama J, Kiyohara C, Handa S, Masuda Y, Kuratsune M. Effects of chlorinated dibenzofuran and dioxin on concentration and pattern of chlorobiphenyls and activity of benzo(a)pyrene hydroxylation in mice. Fukuoka Igaku Zasshi. 1985 May;76(5):175-83. PubMed PMID: 3930367.

20: Ishii K, Maeda K, Kamataki T, Kato R. Mutagenic activation of aflatoxin B1 by several forms of purified cytochrome P-450. Mutat Res. 1986 Jun;174(2):85-8. PubMed PMID: 3086716.