Sulbenicillin disodium

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H558199

CAS#: 28002-18-8

Description: Sulbenicillin disodium is a semisynthetic penicillin-type antibiotic.


Chemical Structure

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Sulbenicillin disodium
CAS# 28002-18-8

Theoretical Analysis

Hodoodo Cat#: H558199
Name: Sulbenicillin disodium
CAS#: 28002-18-8
Chemical Formula: C16H16N2Na2O7S2
Exact Mass: 458.02
Molecular Weight: 458.410
Elemental Analysis: C, 41.92; H, 3.52; N, 6.11; Na, 10.03; O, 24.43; S, 13.99

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Sulbenicillin disodium; alpha-Sulfobenzylpenicillin disodium; Disodium sulbenicillin; Disodium sulfobenzylpenicillin;

IUPAC/Chemical Name: 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-(2-phenyl-2-sulfoacetamido)-, disodium salt

InChi Key: FWRNIJIOFYDBES-UHFFFAOYSA-L

InChi Code: InChI=1S/C16H18N2O7S2.2Na/c1-16(2)11(15(21)22)18-13(20)9(14(18)26-16)17-12(19)10(27(23,24)25)8-6-4-3-5-7-8;;/h3-7,9-11,14H,1-2H3,(H,17,19)(H,21,22)(H,23,24,25);;/q;2*+1/p-2

SMILES Code: O=C(C(C(C)(C)SC1C2NC(C(C3=CC=CC=C3)S(=O)([O-])=O)=O)N1C2=O)[O-].[Na+].[Na+]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 458.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Miyakawa I, Taniyama K, Inoue H, Lee HC, Mori N. Placental transfer of disodium sulbenicillin. Antimicrob Agents Chemother. 1982 May;21(5):838-9. PubMed PMID: 6808913; PubMed Central PMCID: PMC182022.

2: Yoshida H, Higaki Y, Ogawa H, Iguchi H, Watanabe M. [Effect of disodium sulbenicillin (SBPC) for urinary tract infections after retropubic prostatectomy, with special reference to SBPC concentration in human prostatic tissue (author's transl)]. Jpn J Antibiot. 1980 Apr;33(4):522-5. Japanese. PubMed PMID: 7411856.

3: Mochizuki K, Torisaki M, Kawasaki K, Shirao Y, Yamashita Y, Kitano K, Yonemura D. Retinal toxicity of antibiotics: evaluation by electroretinogram. Doc Ophthalmol. 1988 Jun;69(2):195-202. PubMed PMID: 3168722.

4: Hayashi N, Kato S, Morimoto H. Effect of gamma irradiation on disodium alpha-sulfobenzylpenicillin in solid state. Int J Appl Radiat Isot. 1977 Aug;28(8):723-6. PubMed PMID: 892926.

5: Burton G, Best DJ, Dixon RA, Kenyon RF, Lashford AG. Studies on 6 alpha-substituted penicillins. II. Synthesis and structure-activity relationships of 6 beta-(2-aryl-2-sulfoacetamido)-6 alpha-methoxy penicillanic acids. J Antibiot (Tokyo). 1986 Oct;39(10):1419-29. PubMed PMID: 3096924.

6: Kawasaki K, Ohnogi J. Nontoxic concentration of antibiotics for intravitreal use--evaluated by human in-vitro ERG. Doc Ophthalmol. 1988 Dec;70(4):301-8. PubMed PMID: 3251718.

7: Fukuda M, Sasaki K. [Antibiotic ophthalmic solutions evaluated by pharmacokinetic parameters of maximum concentration in the aqueous]. Nippon Ganka Gakkai Zasshi. 2002 Apr;106(4):195-200. Japanese. PubMed PMID: 11979978.

8: Kawasaki K, Ohnogi J, Okayama Y, Yonemura D. Effects of antibiotics on the in vitro ERG of the albino rabbit. Penicillins and cephalosporins antibiotics. Doc Ophthalmol. 1987 May;66(1):75-84. PubMed PMID: 3428073.

9: Burton G, Basker MJ, Bentley PH, Best DJ, Dixon RA, Harrington FP, Kenyon RF, Lashford AG, Taylor AW. Preparation and structure-activity relationships of some 6 alpha-substituted penicillins. J Antibiot (Tokyo). 1985 Jun;38(6):721-39. PubMed PMID: 3926736.

10: Yoshida T, Matsuura S, Mayama M, Kameda Y, Kuwahara S. Moxalactam (6059-S), a novel 1-oxa-beta-lactam with an expanded antibacterial spectrum: laboratory evaluation. Antimicrob Agents Chemother. 1980 Mar;17(3):302-12. PubMed PMID: 6448572; PubMed Central PMCID: PMC283781.