WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H563077
CAS#: 1528729-98-7
Description: HYS-32 is an analogue of combretastatin A-4 that acts by enhancing connexin43 expression.
Hodoodo Cat#: H563077
Name: HYS-32
CAS#: 1528729-98-7
Chemical Formula: C22H18O4
Exact Mass: 346.12
Molecular Weight: 346.380
Elemental Analysis: C, 76.29; H, 5.24; O, 18.48
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Synonym: HYS-32; HYS 32; HYS32;
IUPAC/Chemical Name: 4-(3,4-Dimethoxyphenyl)-3-(naphthalen-2-yl)-2(5H)-furanone
InChi Key: JVWIHSGZUWAJAW-UHFFFAOYSA-N
InChi Code: InChI=1S/C22H18O4/c1-24-19-10-9-16(12-20(19)25-2)18-13-26-22(23)21(18)17-8-7-14-5-3-4-6-15(14)11-17/h3-12H,13H2,1-2H3
SMILES Code: O=C1OCC(C2=CC=C(OC)C(OC)=C2)=C1C3=CC=C4C=CC=CC4=C3
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 346.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Chiu CT, Liao CK, Shen CC, Tang TK, Jow GM, Wang HS, Wu JC. HYS-32-Induced Microtubule Catastrophes in Rat Astrocytes Involves the PI3K-GSK3beta Signaling Pathway. PLoS One. 2015 May 4;10(5):e0126217. doi: 10.1371/journal.pone.0126217. eCollection 2015. PubMed PMID: 25938237; PubMed Central PMCID: PMC4418738.
2: Lin PC, Shen CC, Liao CK, Jow GM, Chiu CT, Chung TH, Wu JC. HYS-32, a novel analogue of combretastatin A-4, enhances connexin43 expression and gap junction intercellular communication in rat astrocytes. Neurochem Int. 2013 May;62(6):881-92. doi: 10.1016/j.neuint.2013.02.027. Epub 2013 Mar 14. PubMed PMID: 23500605.