WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H591666
CAS#: 106224-67-3
Description: NC182 is a topo II inhibitor. NC182 exhibits selective and superior topo II inhibition upon induction of topo II-dependent DNA fragmentation.
Hodoodo Cat#: H591666
Name: NC182
CAS#: 106224-67-3
Chemical Formula: C24H24N4O5
Exact Mass: 448.17
Molecular Weight: 448.480
Elemental Analysis: C, 64.28; H, 5.39; N, 12.49; O, 17.84
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Synonym: NC182; NC 182; NC-182
IUPAC/Chemical Name: methyl 6-((2-(dimethylamino)ethyl)carbamoyl)-5-hydroxy-10-methoxybenzo[a]phenazine-9-carboxylate
InChi Key: DGSXFRJEHFETBL-UHFFFAOYSA-N
InChi Code: InChI=1S/C24H24N4O5/c1-28(2)10-9-25-23(30)19-21-20(13-7-5-6-8-14(13)22(19)29)26-17-12-18(32-3)15(24(31)33-4)11-16(17)27-21/h5-8,11-12,29H,9-10H2,1-4H3,(H,25,30)
SMILES Code: O=C(C1=CC2=NC3=C(C(NCCN(C)C)=O)C(O)=C4C(C=CC=C4)=C3N=C2C=C1OC)OC
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 448.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Apostolova LG, Hwang KS, Kohannim O, Avila D, Elashoff D, Jack CR Jr, Shaw L, Trojanowski JQ, Weiner MW, Thompson PM; Alzheimer's Disease Neuroimaging Initiative. ApoE4 effects on automated diagnostic classifiers for mild cognitive impairment and Alzheimer's disease. Neuroimage Clin. 2014 Jan 4;4:461-72. doi: 10.1016/j.nicl.2013.12.012. eCollection 2014. PubMed PMID: 24634832; PubMed Central PMCID: PMC3952354.
2: Moorthy NS, Pratheepa V, Ramos MJ, Vasconcelos V, Fernandes PA. Fused aryl-phenazines: scaffold for the development of bioactive molecules. Curr Drug Targets. 2014;15(7):681-8. Review. PubMed PMID: 24499398.
3: Tarui M, Doi M, Ishida T, Inoue M, Nakaike S, Kitamura K. DNA-binding characterization of a novel anti-tumour benzo[a]phenazine derivative NC-182: spectroscopic and viscometric studies. Biochem J. 1994 Nov 15;304 ( Pt 1):271-9. PubMed PMID: 7998945; PubMed Central PMCID: PMC1137482.