WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H563112
CAS#: 1421931-14-7
Description: SW120 is a fluorescent sigma-2 selective ligand.
Hodoodo Cat#: H563112
Name: SW120
CAS#: 1421931-14-7
Chemical Formula: C33H48N6O7
Exact Mass: 640.36
Molecular Weight: 640.780
Elemental Analysis: C, 61.86; H, 7.55; N, 13.12; O, 17.48
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Synonym: SW120; SW-120; SW 120;
IUPAC/Chemical Name: (2,5-Dimethoxy-phenyl)-carbamic acid 9-[10-(7-nitro-benzo[1,2,5]oxadiazol-4-ylamino)-decyl]-9-aza-bicyclo[3.3.1]non-3-yl ester
InChi Key: BHCVRPVATGCNGN-UHFFFAOYSA-N
InChi Code: InChI=1S/C33H48N6O7/c1-43-26-14-16-31(44-2)29(22-26)36-33(40)45-27-20-24-12-11-13-25(21-27)37(24)19-10-8-6-4-3-5-7-9-18-34-28-15-17-32(39(41)42)38-30(28)23-35-46-38/h14-17,22-25,27,34-35H,3-13,18-21H2,1-2H3,(H,36,40)
SMILES Code: O=C(OC1CC(N2CCCCCCCCCCNC3=CC=C([N+]([O-])=O)N4C3=CNO4)CCCC2C1)NC5=CC(OC)=CC=C5OC
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 640.78 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
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2: Zeng C, Garg N, Mach RH. The PGRMC1 Protein Level Correlates with the Binding Activity of a Sigma-2 Fluorescent Probe (SW120) in Rat Brain Cells. Mol Imaging Biol. 2016 Apr;18(2):172-9. doi: 10.1007/s11307-015-0891-z. PubMed PMID: 26335282.
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7: Reinsch N, Looft C, Rudat I, Kalm E. The Kiel RN experiment: final porcine chromosome 15 mapping results. J Anim Breed Genet. 1997 Jan 12;114(1-6):133-42. doi: 10.1111/j.1439-0388.1997.tb00500.x. PubMed PMID: 21395810.
8: Milan D, Woloszyn N, Yerle M, Le Roy P, Bonnet M, Riquet J, Lahbib-Mansais Y, Caritez JC, Robic A, Sellier P, Elsen JM, Gellin J. Accurate mapping of the "acid meat" RN gene on genetic and physical maps of pig chromosome 15. Mamm Genome. 1996 Jan;7(1):47-51. PubMed PMID: 8903728.