WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H563138
CAS#: 691868-88-9
Description: RO8191 is an activator of JAK/STAT that induces IFN-like signals.
Hodoodo Cat#: H563138
Name: RO8191
CAS#: 691868-88-9
Chemical Formula: C14H5F6N5O
Exact Mass: 373.04
Molecular Weight: 373.210
Elemental Analysis: C, 45.06; H, 1.35; F, 30.54; N, 18.77; O, 4.29
Synonym: RO8191; RO-8191; RO 8191; RO4948191; RO 4948191; RO-4948191;
IUPAC/Chemical Name: 8-(1,3,4-Oxadiazol-2-yl)-2,4-bis(trifluoromethyl)-imidazo[1,2-a][1,8]naphthyridine
InChi Key: GRHYZVJEXKTJOS-UHFFFAOYSA-N
InChi Code: InChI=1S/C14H5F6N5O/c15-13(16,17)7-3-9(14(18,19)20)23-11-6(7)1-2-10-22-8(4-25(10)11)12-24-21-5-26-12/h1-5H
SMILES Code: FC(C1=C2C=CC3=NC(C4=NN=CO4)=CN3C2=NC(C(F)(F)F)=C1)(F)F
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 373.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Wang H, Wang S, Cheng L, Chen L, Wang Y, Qing J, Huang S, Wang Y, Lei X, Wu Y, Ma Z, Zhang L, Tang Y. Discovery of Imidazo[1,2-α][1,8]naphthyridine Derivatives as Potential HCV Entry Inhibitor. ACS Med Chem Lett. 2015 Jul 27;6(9):977-81. doi: 10.1021/acsmedchemlett.5b00159. eCollection 2015 Sep 10. PubMed PMID: 26396683; PubMed Central PMCID: PMC4569878.
2: Huang S, Qing J, Wang S, Wang H, Zhang L, Tang Y. Design and synthesis of imidazo[1,2-α][1,8]naphthyridine derivatives as anti-HCV agents via direct C-H arylation. Org Biomol Chem. 2014 Apr 21;12(15):2344-8. doi: 10.1039/c3ob42525h. PubMed PMID: 24595428.