LM22B-10
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Hodoodo CAT#: H555271

CAS#: 342777-54-2

Description: LM22B-10 is a TrkB and TrkC agonist. LM22B-10 exhibits neurotrophic activity (EC50 = 200-300 nM). LM22B-10 improves survival and increases neurite outgrowth in hippocampal cells in vitro. LM22B-10 increased cell survival and strongly accelerated neurite outgrowth, superseding the effects of brain-derived neurotrophic factor (BDNF), NT-3 or the two combined.

Chemical Structure

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LM22B-10
CAS# 342777-54-2
Instruction

Theoretical Analysis

Hodoodo Cat#: H555271
Name: LM22B-10
CAS#: 342777-54-2
Chemical Formula: C27H33ClN2O4
Exact Mass: 484.21
Molecular Weight: 485.021
Elemental Analysis: C, 66.86; H, 6.86; Cl, 7.31; N, 5.78; O, 13.19

Price and Availability

Size Price Availability Quantity
50mg USD 450 2 Weeks
100mg USD 850 2 Weeks
200mg USD 1450 2 Weeks
500mg USD 2250 2 Weeks
1g USD 3450 2 Weeks
2g USD 5650 2 Weeks
5g USD 7850 2 Weeks
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Synonym: LM22B-10; LM22B 10; LM22B10; LM 22B10; LM-22B10; LM22B10;

IUPAC/Chemical Name: 2,2',2',2'''-[[(4-Chlorophenyl)methylene]bis(4,1-phenylenenitrilo)]tetrakisethanol

InChi Key: QCXQLSGBOUUVNH-UHFFFAOYSA-N

InChi Code: InChI=1S/C27H33ClN2O4/c28-24-7-1-21(2-8-24)27(22-3-9-25(10-4-22)29(13-17-31)14-18-32)23-5-11-26(12-6-23)30(15-19-33)16-20-34/h1-12,27,31-34H,13-20H2

SMILES Code: ClC1=CC=C(C(C2=CC=C(N(CCO)CCO)C=C2)C3=CC=C(N(CCO)CCO)C=C3)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 485.02 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Zhang T, Liao JY, Yu L, Liu GS. Regulating effect of glycyrrhetinic acid on
bronchial asthma smooth muscle proliferation and apoptosis as well as
inflammatory factor expression through ERK1/2 signaling pathway. Asian Pac J Trop
Med. 2017 Dec;10(12):1172-1176. doi: 10.1016/j.apjtm.2017.10.025. Epub 2017 Oct
28. PubMed PMID: 29268974.


2: Yang T, Massa SM, Tran KC, Simmons DA, Rajadas J, Zeng AY, Jang T, Carsanaro
S, Longo FM. A small molecule TrkB/TrkC neurotrophin receptor co-activator with
distinctive effects on neuronal survival and process outgrowth.
Neuropharmacology. 2016 Nov;110(Pt A):343-361. doi:
10.1016/j.neuropharm.2016.06.015. Epub 2016 Jun 19. PubMed PMID: 27334657.