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Phenylacetylglutamine
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WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H597278

CAS#: 28047-15-6 (free acid)

Description: Phenylacetylglutamine is used as biomarker for metabolic age.

Chemical Structure

Phenylacetylglutamine

CAS# 28047-15-6 (free acid)

Instruction

Theoretical Analysis

Hodoodo Cat#: H597278
Name: Phenylacetylglutamine
CAS#: 28047-15-6 (free acid)
Chemical Formula: C13H16N2O4
Exact Mass: 264.11
Molecular Weight: 264.281
Elemental Analysis: C, 59.08; H, 6.10; N, 10.60; O, 24.22

Price and Availability

Size	Price	Availability
5g	USD 250	2 Weeks
10g	USD 400	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. Hodoodo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Related CAS #: 104771-87-1 (sodium) 28047-15-6 (free acid)

Synonym: Phenylacetylglutamine; NSC 203800; NSC-203800; NSC203800 PA-L-Glutamine;

IUPAC/Chemical Name: (2-phenylacetyl)-L-glutamine

InChi Key: JFLIEFSWGNOPJJ-JTQLQIEISA-N

InChi Code: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/t10-/m0/s1

SMILES Code: O=C(N)CC[C@@H](C(O)=O)NC(CC1=CC=CC=C1)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 264.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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10: Lario S, Ramírez-Lázaro MJ, Sanjuan-Herráez D, Brunet-Vega A, Pericay C, Gombau L, Junquera F, Quintás G, Calvet X. Plasma sample based analysis of gastric cancer progression using targeted metabolomics. Sci Rep. 2017 Dec 19;7(1):17774. doi: 10.1038/s41598-017-17921-x. PubMed PMID: 29259332; PubMed Central PMCID: PMC5736578.

11: Stravitz RT, Gottfried M, Durkalski V, Fontana RJ, Hanje AJ, Koch D, Hameed B, Ganger D, Subramanian RM, Bukofzer S, Ravis WR, Clasen K, Sherker A, Little L, Lee WM; Acute Liver Failure Study Group. Safety, tolerability, and pharmacokinetics of l-ornithine phenylacetate in patients with acute liver injury/failure and hyperammonemia. Hepatology. 2018 Mar;67(3):1003-1013. doi: 10.1002/hep.29621. Epub 2018 Jan 30. PubMed PMID: 29080224; PubMed Central PMCID: PMC5826861.

12: van Straten G, de Sain-van der Velden MGM, van Geijlswijk IM, Favier RP, Mesu SJ, Holwerda-Loof NE, van der Ham M, Fieten H, Rothuizen J, Spee B, Verhoeven-Duif NM. Saline is as effective as nitrogen scavengers for treatment of hyperammonemia. Sci Rep. 2017 Oct 13;7(1):13112. doi: 10.1038/s41598-017-12686-9. PubMed PMID: 29030642; PubMed Central PMCID: PMC5640627.

13: Peña-Quintana L, Llarena M, Reyes-Suárez D, Aldámiz-Echevarria L. Profile of sodium phenylbutyrate granules for the treatment of urea-cycle disorders: patient perspectives. Patient Prefer Adherence. 2017 Sep 6;11:1489-1496. doi: 10.2147/PPA.S136754. eCollection 2017. Review. PubMed PMID: 28919721; PubMed Central PMCID: PMC5593420.

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20: Poesen R, Claes K, Evenepoel P, de Loor H, Augustijns P, Kuypers D, Meijers B. Microbiota-Derived Phenylacetylglutamine Associates with Overall Mortality and Cardiovascular Disease in Patients with CKD. J Am Soc Nephrol. 2016 Nov;27(11):3479-3487. Epub 2016 May 26. PubMed PMID: 27230658; PubMed Central PMCID: PMC5084895.

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