WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H597321
CAS#: 130024-92-9
Description: S 863390 is a renin inhibitor.
Hodoodo Cat#: H597321
Name: S 863390
CAS#: 130024-92-9
Chemical Formula: C37H52N6O4
Exact Mass: 644.41
Molecular Weight: 644.860
Elemental Analysis: C, 68.92; H, 8.13; N, 13.03; O, 9.92
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Synonym: S 863390; S-863390; S863390; S 86,3390; S-86,3390 S86,3390;
IUPAC/Chemical Name: N-((S)-1-(((S)-1-amino-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl)((2S,3S)-1-cyclohexyl-3-hydroxy-6-(pyridin-2-yl)hexan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)-3-methylbutanamide
InChi Key: GSANUXXPZGRAIH-CUPIEXAXSA-N
InChi Code: InChI=1S/C37H52N6O4/c1-26(2)20-35(45)42-31(21-27-12-5-3-6-13-27)37(47)43(33(36(38)46)23-30-24-39-25-41-30)32(22-28-14-7-4-8-15-28)34(44)18-11-17-29-16-9-10-19-40-29/h3,5-6,9-10,12-13,16,19,24-26,28,31-34,44H,4,7-8,11,14-15,17-18,20-23H2,1-2H3,(H2,38,46)(H,39,41)(H,42,45)/t31-,32-,33-,34-/m0/s1
SMILES Code: O=C(N)[C@H](CC1=CNC=N1)N(C([C@H](CC2=CC=CC=C2)NC(CC(C)C)=O)=O)[C@@H](CC3CCCCC3)[C@@H](O)CCCC4=NC=CC=C4
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 644.86 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Kramer W, Girbig F, Gutjahr U, Kleemann HW, Leipe I, Urbach H, Wagner A. Interaction of renin inhibitors with the intestinal uptake system for oligopeptides and beta-lactam antibiotics. Biochim Biophys Acta. 1990 Aug 10;1027(1):25-30. PubMed PMID: 2204426.