WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H597352
CAS#: 61473-66-3
Description: S-Hydroxyethylhomocysteine is a bioactive chemical.
Hodoodo Cat#: H597352
Name: S-Hydroxyethylhomocysteine
CAS#: 61473-66-3
Chemical Formula: C6H13NO3S
Exact Mass: 179.06
Molecular Weight: 179.230
Elemental Analysis: C, 40.21; H, 7.31; N, 7.81; O, 26.78; S, 17.89
This product is not in stock, which may be available by custom synthesis.
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Synonym: S-Hydroxyethylhomocysteine;
IUPAC/Chemical Name: S-(2-hydroxyethyl)-L-homocysteine
InChi Key: WKECILUJKOJNGE-YFKPBYRVSA-N
InChi Code: InChI=1S/C6H13NO3S/c7-5(6(9)10)1-3-11-4-2-8/h5,8H,1-4,7H2,(H,9,10)/t5-/m0/s1
SMILES Code: N[C@@H](CCSCCO)C(O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 179.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Douša M. The determination of pharmaceutically active thiols using hydrophilic interaction chromatography followed postcolumn derivatization with o-phthaldialdehyde and fluorescence detection. J Pharm Biomed Anal. 2018 Jul 15;156:1-7. doi: 10.1016/j.jpba.2018.04.007. Epub 2018 Apr 16. PubMed PMID: 29684906.
2: Hopwood EM, Ahmed D, Aitken SM. A role for glutamate-333 of Saccharomyces cerevisiae cystathionine γ-lyase as a determinant of specificity. Biochim Biophys Acta. 2014 Feb;1844(2):465-72. doi: 10.1016/j.bbapap.2013.11.012. Epub 2013 Nov 28. PubMed PMID: 24291053.
3: Martín-Venegas R, Brufau MT, Guerrero-Zamora AM, Mercier Y, Geraert PA, Ferrer R. The methionine precursor DL-2-hydroxy-(4-methylthio)butanoic acid protects intestinal epithelial barrier function. Food Chem. 2013 Dec 1;141(3):1702-9. doi: 10.1016/j.foodchem.2013.04.081. Epub 2013 May 3. PubMed PMID: 23870881.
4: Nishi T, Kouda N, Watanabe K, Tanaka Y, Araki K, Furihata K, Onodera M, Toda K. Accumulation of S-2-hydroxyethyl derivatives of L-cysteine and L-homocysteine by a methionine auxotroph of Escherichia coli with the addition of 2-mercaptoethanol to the culture. J Biosci Bioeng. 2004;97(2):134-7. PubMed PMID: 16233605.
5: Caro AA, Cederbaum AI. Inhibition of CYP2E1 catalytic activity in vitro by S-adenosyl-L-methionine. Biochem Pharmacol. 2005 Apr 1;69(7):1081-93. PubMed PMID: 15763544.
6: Papadopoulos AI, Walker J, Barrett J. A novel cystathionine beta-synthase from Panagrellus redivivus (Nematoda). Int J Biochem Cell Biol. 1996 May;28(5):543-9. PubMed PMID: 8697099.
7: Puri RN, Bhatnagar D, Roskoski R Jr. Adenosine cyclic 3',5'-monophosphate dependent protein kinase: fluorescent affinity labeling of the catalytic subunit from bovine skeletal muscle with o-phthalaldehyde. Biochemistry. 1985 Nov 5;24(23):6499-508. PubMed PMID: 3936543.
8: De Clercq E, Holý A. Alkyl esters of 3-adenin-9-yl-2-hydroxypropanoic acid: a new class of broad-spectrum antiviral agents. J Med Chem. 1985 Mar;28(3):282-7. PubMed PMID: 3973900.