WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H597382
CAS#: 75790-53-3
Description: Dynorphin (1-8) is an opioid octapeptide from porcine hypothalamus; comprises the N-terminal eight residues of dynorphin.
Hodoodo Cat#: H597382
Name: Dynorphin (1-8)
CAS#: 75790-53-3
Chemical Formula: C46H72N14O10
Exact Mass: 980.56
Molecular Weight: 981.170
Elemental Analysis: C, 56.31; H, 7.40; N, 19.99; O, 16.31
This product is not in stock, which may be available by custom synthesis.
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Synonym: Dynorphin (1-8); PH-8P;
IUPAC/Chemical Name: L-tyrosylglycylglycyl-L-phenylalanyl-L-leucyl-L-arginyl-L-arginyl-L-isoleucine
InChi Key: WRPLGMBDXVBPEG-VGXZEHLRSA-N
InChi Code: InChI=1S/C46H72N14O10/c1-5-27(4)38(44(69)70)60-41(66)33(14-10-20-53-46(50)51)57-40(65)32(13-9-19-52-45(48)49)58-42(67)34(21-26(2)3)59-43(68)35(23-28-11-7-6-8-12-28)56-37(63)25-54-36(62)24-55-39(64)31(47)22-29-15-17-30(61)18-16-29/h6-8,11-12,15-18,26-27,31-35,38,61H,5,9-10,13-14,19-25,47H2,1-4H3,(H,54,62)(H,55,64)(H,56,63)(H,57,65)(H,58,67)(H,59,68)(H,60,66)(H,69,70)(H4,48,49,52)(H4,50,51,53)/t27-,31-,32-,33-,34-,35-,38-/m0/s1
SMILES Code: Oc1ccc(C[C@H](N)C(NCC(NCC(N[C@@H](Cc2ccccc2)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H]([C@@H](C)CC)C(O)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CC(C)C)=O)=O)=O)=O)cc1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 981.17 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
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3: Molnár CS, Sárvári M, Vastagh C, Maurnyi C, Fekete C, Liposits Z, Hrabovszky E. Altered Gene Expression Profiles of the Hypothalamic Arcuate Nucleus of Male Mice Suggest Profound Developmental Changes in Peptidergic Signaling. Neuroendocrinology. 2016;103(3-4):369-82. doi: 10.1159/000439430. Epub 2015 Aug 25. PubMed PMID: 26338351.
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9: Ruisanchez É, Cselenyák A, Papp RS, Németh T, Káldi K, Sándor P, Benyó Z. Perivascular expression and potent vasoconstrictor effect of dynorphin A in cerebral arteries. PLoS One. 2012;7(5):e37798. doi: 10.1371/journal.pone.0037798. Epub 2012 May 25. PubMed PMID: 22662226; PubMed Central PMCID: PMC3360594.
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13: Hanrieder J, Ljungdahl A, Fälth M, Mammo SE, Bergquist J, Andersson M. L-DOPA-induced dyskinesia is associated with regional increase of striatal dynorphin peptides as elucidated by imaging mass spectrometry. Mol Cell Proteomics. 2011 Oct;10(10):M111.009308. doi: 10.1074/mcp.M111.009308. Epub 2011 Jul 6. PubMed PMID: 21737418; PubMed Central PMCID: PMC3205869.
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