Welcome to Hodoodo Chemicals

Acridine
featured

WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H591964

CAS#: 260-94-6

Description: Acridine is an organic compound and a nitrogen heterocycle with the formula C13H9N. Acridines are substituted derivatives of the parent ring. Several dyes and drugs feature the acridine skeleton.

Chemical Structure

Acridine

CAS# 260-94-6

Instruction

Theoretical Analysis

Hodoodo Cat#: H591964
Name: Acridine
CAS#: 260-94-6
Chemical Formula: C13H9N
Exact Mass: 179.07
Molecular Weight: 179.220
Elemental Analysis: C, 87.12; H, 5.06; N, 7.82

Price and Availability

Size	Price	Availability
5g	USD 220	2 Weeks
10g	USD 360	2 Weeks
25g	USD 610	2 Weeks
50g	USD 940	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. Hodoodo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Acridine; NSC 3408; NSC-3408; NSC3408; 2,3,5,6-Dibenzopyridine; 10-Azaanthracene; Dibenzopyridine; 2,3,5,6Dibenzopyridine; 10Azaanthracene; 2,3,5,6 Dibenzopyridine; 10 Azaanthracene

IUPAC/Chemical Name: Acridine

InChi Key: DZBUGLKDJFMEHC-UHFFFAOYSA-N

InChi Code: InChI=1S/C13H9N/c1-3-7-12-10(5-1)9-11-6-2-4-8-13(11)14-12/h1-9H

SMILES Code: C12=NC3=CC=CC=C3C=C1C=CC=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	10.0	55.80
	DMF	2.0	11.16
	Ethanol	10.0	55.80

Preparing Stock Solutions

The following data is based on the product molecular weight 179.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

1: Hubenko KO, Yefimova SL, Tkacheva TN, Maksimchuk PO, Sedyh OO, Viagin OG, Sorokin AV, Malyukin YV. Excimer Emission of Acridine Orange Adsorbed on Gadolinium-Yttrium Orthovanadate Nanoparticles. J Fluoresc. 2018 Jun 30. doi: 10.1007/s10895-018-2257-9. [Epub ahead of print] PubMed PMID: 29961203.

2: Chen J, Li D, Li W, Yin J, Zhang Y, Yuan Z, Gao C, Liu F, Jiang Y. Design, synthesis and anticancer evaluation of acridine hydroxamic acid derivatives as dual Topo and HDAC inhibitors. Bioorg Med Chem. 2018 Jun 20. pii: S0968-0896(18)30627-8. doi: 10.1016/j.bmc.2018.06.016. [Epub ahead of print] PubMed PMID: 29954683.

3: Liu T, Wang YA, Zang Q, Zhong GQ. Hydrothermal Synthesis, Structural Characterization, and Interaction Mechanism with DNA of Copper(II) Complex Containing 2,2'-Bipyridine. Bioinorg Chem Appl. 2018 May 22;2018:8459638. doi: 10.1155/2018/8459638. eCollection 2018. PubMed PMID: 29951088; PubMed Central PMCID: PMC5987339.

4: Lu SY, Mukhopadhyay S, Froese RDJ, Zimmerman PM. Virtual Screening of Hole Transport, Electron Transport, and HOST Layers for Effective OLED Design. J Chem Inf Model. 2018 Jun 27. doi: 10.1021/acs.jcim.8b00044. [Epub ahead of print] PubMed PMID: 29949358.

5: Zhu FR, Li YN, He SL, Chen QS, Xu XY. Cytotoxic Activities of Total Saponins from Plena Clematis on Human Tumor Cell Lines In Vitro. Chin J Integr Med. 2018 Jun 21. doi: 10.1007/s11655-018-2839-z. [Epub ahead of print] PubMed PMID: 29926388.

6: Luo X, Ye S, Jiang Q, Gong Y, Yuan Y, Hu X, Su X, Zhu W. Wnt inhibitory factor-1-mediated autophagy inhibits Wnt/β-catenin signaling by downregulating dishevelled-2 expression in non-small cell lung cancer cells. Int J Oncol. 2018 Jun 15. doi: 10.3892/ijo.2018.4442. [Epub ahead of print] PubMed PMID: 29916529.

7: Wainwright M. Synthetic, small-molecule photoantimicrobials - a realistic approach. Photochem Photobiol Sci. 2018 Jun 15. doi: 10.1039/c8pp00145f. [Epub ahead of print] PubMed PMID: 29905338.

8: Kim S, Han SH, Mishra NK, Chun R, Jung YH, Kim HS, Park JS, Kim IS. Dual Role of Anthranils as Amination and Transient Directing Group Sources: Synthesis of 2-Acyl Acridines. Org Lett. 2018 Jun 15. doi: 10.1021/acs.orglett.8b01571. [Epub ahead of print] PubMed PMID: 29905072.

9: Tang S, Zhang S, Chen W, Quan C, Duan P, Huang W, Wang A, Yang K. [Effects of fluoride on autophagy level in human neuroblastoma SH-SY5Y cells]. Wei Sheng Yan Jiu. 2017 May;46(3):472-480. Chinese. PubMed PMID: 29903262.

10: Elhinnawi MA, Mohareb RM, Rady HM, Khalil WKB, Abd Elhalim MM, Elmegeed GA. Novel pregnenolone derivatives modulate apoptosis via Bcl-2 family genes in hepatocellular carcinoma in vitro. J Steroid Biochem Mol Biol. 2018 Jun 10. pii: S0960-0760(18)30178-X. doi: 10.1016/j.jsbmb.2018.06.006. [Epub ahead of print] PubMed PMID: 29898413.

11: Wang B, Han J, Bojanowski NM, Bender M, Ma C, Seehafer K, Herrmann A, Bunz UHF. An Optimized Sensor Array Identifies All Natural Amino Acids. ACS Sens. 2018 Jun 26. doi: 10.1021/acssensors.8b00371. [Epub ahead of print] PubMed PMID: 29896952.

12: Duan Z, Chen Q, Du L, Tong J, Xu S, Zeng R, Ma Y, Chen X, Li M. Phagocytosis of Candida albicans Inhibits Autophagic Flux in Macrophages. Oxid Med Cell Longev. 2018 May 20;2018:4938649. doi: 10.1155/2018/4938649. eCollection 2018. PubMed PMID: 29887941; PubMed Central PMCID: PMC5985103.

13: Sun FQ, Li MQ, Peng SH, Zhang HM, Liu M, Qu XY. [Study on antibacterial properties and osteoblast activity of antimicrobial peptide coatings on titanium implants]. Zhonghua Kou Qiang Yi Xue Za Zhi. 2018 Jun 9;53(6):419-424. doi: 10.3760/cma.j.issn.1002-0098.2018.06.011. Chinese. PubMed PMID: 29886638.

14: Nakamura T, Kusuzaki K, Matsubara T, Murata H, Hagi T, Asanuma K, Sudo A. Long-term clinical outcome in patients with high-grade soft tissue sarcoma who were treated with surgical adjuvant therapy using acridine orange after intra-lesional or marginal resection. Photodiagnosis Photodyn Ther. 2018 Jun 7. pii: S1572-1000(18)30082-6. doi: 10.1016/j.pdpdt.2018.06.001. [Epub ahead of print] PubMed PMID: 29885811.

15: Baharara J, Ramezani T, Hosseini N, Mousavi M. Silver Nanoparticles Synthesized Coating with Zataria Multiflora Leaves Extract Induced Apoptosis in HeLa Cells Through p53 Activation. Iran J Pharm Res. 2018 Spring;17(2):627-639. PubMed PMID: 29881420; PubMed Central PMCID: PMC5985180.

16: Barnea I, Karako L, Mirsky SK, Levi M, Balberg M, Shaked NT. Stained-free interferometric phase microscopy correlation with DNA fragmentation stain in human spermatozoa. J Biophotonics. 2018 Jun 7:e201800137. doi: 10.1002/jbio.201800137. [Epub ahead of print] PubMed PMID: 29877620.

17: Rezakhaniha B, Heidari R, Abbasi M. Can Melissa officinalis improve chromatin structure and sperm parameters in a rat model of varicocele? Andrologia. 2018 Jun 6:e13058. doi: 10.1111/and.13058. [Epub ahead of print] PubMed PMID: 29876952.

18: Fan B, You J, Suo Y, Qian C. A novel and sensitive method for determining vitamin B3 and B7 by pre-column derivatization and high-performance liquid chromatography method with fluorescence detection. PLoS One. 2018 Jun 6;13(6):e0198102. doi: 10.1371/journal.pone.0198102. eCollection 2018. PubMed PMID: 29874249; PubMed Central PMCID: PMC5991410.

19: Khan FZ, Hutcheson JA, Hunter CJ, Powless AJ, Benson D, Fritsch I, Muldoon TJ. Redox-Magnetohydrodynamically Controlled Fluid Flow with Poly(3,4-ethylenedioxythiophene) Coupled to an Epitaxial Light Sheet Confocal Microscope for Image Cytometry Applications. Anal Chem. 2018 Jun 21. doi: 10.1021/acs.analchem.7b05312. [Epub ahead of print] PubMed PMID: 29873231.

20: Chufarova N, Czarnecka K, Skibiński R, Cuchra M, Majsterek I, Szymański P. New tacrine-acridine hybrids as promising multifunctional drugs for potential treatment of Alzheimer's disease. Arch Pharm (Weinheim). 2018 Jun 5:e1800050. doi: 10.1002/ardp.201800050. [Epub ahead of print] PubMed PMID: 29870588.

Your view history

Acridine featured