Phorphin

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H597461

CAS#: 88847-78-3

Description: Phorphin is the fourth repeating peptide in prodinorphin.

Chemical Structure

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Phorphin
CAS# 88847-78-3
Instruction

Theoretical Analysis

Hodoodo Cat#: H597461
Name: Phorphin
CAS#: 88847-78-3
Chemical Formula: C36H50N6O8S
Exact Mass: 726.34
Molecular Weight: 726.890
Elemental Analysis: C, 59.49; H, 6.93; N, 11.56; O, 17.61; S, 4.41

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Phorphin;

IUPAC/Chemical Name: L-tyrosyl-L-methionylglycyl-L-prolyl-L-phenylalanyl-L-leucine

InChi Key: OZTKUZMZLPEQQW-IIZANFQQSA-N

InChi Code: InChI=1S/C36H50N6O8S/c1-22(2)18-29(36(49)50)41-34(47)28(20-23-8-5-4-6-9-23)40-35(48)30-10-7-16-42(30)31(44)21-38-33(46)27(15-17-51-3)39-32(45)26(37)19-24-11-13-25(43)14-12-24/h4-6,8-9,11-14,22,26-30,43H,7,10,15-21,37H2,1-3H3,(H,38,46)(H,39,45)(H,40,48)(H,41,47)(H,49,50)/t26-,27-,28-,29-,30-/m0/s1

SMILES Code: CC(C)C[C@@H](C(O)=O)NC([C@H](CC1=CC=CC=C1)NC([C@H]2N(C(CNC([C@H](CCSC)NC([C@H](CC3=CC=C(O)C=C3)N)=O)=O)=O)CCC2)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 726.89 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Krasnoshchekov SV, Stepanov NF. Nonempirical anharmonic vibrational perturbation theory applied to biomolecules: free-base porphin. J Phys Chem A. 2015 Mar 5;119(9):1616-27. doi: 10.1021/jp5077092. Epub 2014 Nov 18. PubMed PMID: 25360995.

2: Valiev RR, Cherepanov VN, Artyukhov VY, Sundholm D. Computational studies of photophysical properties of porphin, tetraphenylporphyrin and tetrabenzoporphyrin. Phys Chem Chem Phys. 2012 Aug 28;14(32):11508-17. doi: 10.1039/c2cp40468k. Epub 2012 Jul 17. PubMed PMID: 22805735.

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6: Minaev B. Theoretical study of the external heavy atom effect on phosphorescence of free-base porphin molecule. Spectrochim Acta A Mol Biomol Spectrosc. 2004 Nov;60(13):3213-24. PubMed PMID: 15477166.

7: Chaudhuri RK, Freed KF, Chattopadhyay S, Mahapatra US. Application of an efficient multireference approach to free-base porphin and metalloporphyrins: ground, excited, and positive ion states. J Chem Phys. 2011 Aug 28;135(8):084118. doi: 10.1063/1.3627153. PubMed PMID: 21895170.

8: KRASNOVSKII AA, UMRIKHINA AV. [ON ABIOGENIC FORMATION OF PORPHIN AND ITS ROLE IN THE PROCESS OF PHOTOCHEMICAL ELECTRON TRANSPORT]. Dokl Akad Nauk SSSR. 1964 Mar 21;155:691-3. Russian. PubMed PMID: 14236082.

9: Seda J, Burda JV, Leszczynski J. Study of electronic spectra of free-base porphin and Mg-porphin: comprehensive comparison of variety of ab initio, DFT, and semiempirical methods. J Comput Chem. 2005 Feb;26(3):294-303. PubMed PMID: 15622549.

10: Huang WY, Van Riper E, Johnson LW. Single site electronic spectra of free base porphin in an n-octane crystal at 5 K. Spectrochim Acta A Mol Biomol Spectrosc. 1997 Apr;53A(4):589-94. PubMed PMID: 9177040.

11: GILDER H, GRANICK S. Studies on the Hemophilus group of organisms; quantitative aspects of growth on various porphin compounds. J Gen Physiol. 1947 Nov 20;31(2):103-17. PubMed PMID: 18896933; PubMed Central PMCID: PMC2147097.

12: Valiev RR, Fliegl H, Sundholm D. Predicting the degree of aromaticity of novel carbaporphyrinoids. Phys Chem Chem Phys. 2015 Jun 7;17(21):14215-22. doi: 10.1039/c5cp01306b. Epub 2015 May 11. PubMed PMID: 25958951.

13: Minaev B, Wang YH, Wang CK, Luo Y, Agren H. Density functional theory study of vibronic structure of the first absorption Qx band in free-base porphin. Spectrochim Acta A Mol Biomol Spectrosc. 2006 Oct;65(2):308-23. Epub 2006 Aug 17. PubMed PMID: 16920011.

14: Lee BH, Park MB, Yu BS. Inhibition of electric eel acetylcholinesterase by porphin compounds. Bioorg Med Chem Lett. 1998 Jun 16;8(12):1467-70. PubMed PMID: 9873371.

15: Yi J, Campbell ALO, Richter-Addo GB. Nitric oxide coupling to generate N(2)O promoted by a single-heme system as examined by density functional theory. Nitric Oxide. 2016 Nov 30;60:69-75. doi: 10.1016/j.niox.2016.09.004. Epub 2016 Sep 16. PubMed PMID: 27646954.

16: Verma AL, Bernstein HJ. Resonance Raman spectra of metal-free porphin and some prophyrins. Biochem Biophys Res Commun. 1974 Mar 15;57(1):255-62. PubMed PMID: 4828187.

17: Krasnovkiĭ AA, Umrikhina AV. [Abiogenic formation of porphin, chlorine and bacterioclorine]. Dokl Akad Nauk SSSR. 1972 Jan 1;202(1):221-4. Russian. PubMed PMID: 5059696.

18: Moon SC, Shin JH, Jeong BH, Kim HS, Yu BS, Lee JS, Lee BS, Namgoong SK. Synthesis of tetrakis(multifluoro-4-pyridyl)porphin derivatives as acetylcholinesterase inhibitors. Bioorg Med Chem Lett. 2000 Jul 3;10(13):1435-8. PubMed PMID: 10888326.

19: Lapes M, Petera J, Jirsa M. Photodynamic therapy of cutaneous metastases of breast cancer after local application of meso-tetra-(para-sulphophenyl)-porphin (TPPS4). J Photochem Photobiol B. 1996 Nov;36(2):205-7. PubMed PMID: 9002262.

20: Drach JE, Longo FR. Electrophilic substitution on porphin. I. Nitration. J Org Chem. 1974 Nov 1;39(22):3282-4. PubMed PMID: 4424935.