WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H597479
CAS#: 52152-25-7
Description: Albutoin, (S)- is a new thiohydantoin derivative for grand mal epilepsies.
Hodoodo Cat#: H597479
Name: Albutoin, (S)-
CAS#: 52152-25-7
Chemical Formula: C10H16N2OS
Exact Mass: 212.10
Molecular Weight: 212.310
Elemental Analysis: C, 56.57; H, 7.60; N, 13.19; O, 7.54; S, 15.10
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Synonym: Albutoin, (S)-; L-Leucine-3-allyl-2-thiohydantoin;
IUPAC/Chemical Name: (S)-3-allyl-5-isobutyl-2-thioxoimidazolidin-4-one
InChi Key: RATGSRSDPNECNO-QMMMGPOBSA-N
InChi Code: InChI=1S/C10H16N2OS/c1-4-5-12-9(13)8(6-7(2)3)11-10(12)14/h4,7-8H,1,5-6H2,2-3H3,(H,11,14)/t8-/m0/s1
SMILES Code: O=C([C@H](CC(C)C)N1)N(CC=C)C1=S
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 212.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Green JR, Miller LH, Burnett PD, Ward AA Jr. Clinical evaluation of albutoin. Neurology. 1969 Dec;19(12):1207-11. PubMed PMID: 4901181.
2: Wallin RF, Blackburn WH, Napoli MD. Pharmacologic interactions of albutoin with other anticonvulsant drugs. J Pharmacol Exp Ther. 1970 Aug;174(2):276-82. PubMed PMID: 5451364.
3: Cereghino JJ, Brock JT, Van Meter JC, Penry JK, Smith LD, Fisher P, Ellenberg J. Evaluation of albutoin as an antiepileptic drug. Clin Pharmacol Ther. 1974 Apr;15(4):406-16. PubMed PMID: 4206927.
4: Millichap JG, Ortiz WR. Albutoin, a new thiohydantoin derivative for grand mal epilepsies. Comparison with diphenylhydantoin in a double-blind, controlled study. Neurology. 1967 Feb;17(2):162-5. PubMed PMID: 4959915.