WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H597508
CAS#: 110816-78-9
Description: N 556 is a prodrug for disodium cromoglycate.
Hodoodo Cat#: H597508
Name: N 556
CAS#: 110816-78-9
Chemical Formula: C33H38Cl2N2O12
Exact Mass: 0.00
Molecular Weight: 725.560
Elemental Analysis: C, 54.63; H, 5.28; Cl, 9.77; N, 3.86; O, 26.46
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Synonym: N 556; N-556; N556; KY-556; KY556;
IUPAC/Chemical Name: diethyl 5,5'-((2-((2,6-diaminohexanoyl)oxy)propane-1,3-diyl)bis(oxy))(S)-bis(4-oxo-4H-chromene-2-carboxylate) dihydrochloride
InChi Key: VZZTWOVKCVPTSM-FJSYBICCSA-N
InChi Code: InChI=1S/C33H36N2O12.2ClH/c1-3-41-32(39)27-15-21(36)29-23(10-7-12-25(29)46-27)43-17-19(45-31(38)20(35)9-5-6-14-34)18-44-24-11-8-13-26-30(24)22(37)16-28(47-26)33(40)42-4-2;;/h7-8,10-13,15-16,19-20H,3-6,9,14,17-18,34-35H2,1-2H3;2*1H/t20-;;/m0../s1
SMILES Code: N[C@@H](CCCCN)C(OC(COC1=C2C(C=C(C(OCC)=O)OC2=CC=C1)=O)COC3=C4C(C=C(C(OCC)=O)OC4=CC=C3)=O)=O.[H]Cl.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 725.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Yoshimi A, Hashizume H, Kitagawa M, Nishimura K, Kakeya N. Absorption mechanism of 1,3-bis(2-ethoxycarbonylchromon-5-yloxy)-2-((S)-lysyloxy )propane dihydrochloride (N-556), a prodrug for the oral delivery of disodium cromoglycate. Biol Pharm Bull. 1993 Apr;16(4):375-8. PubMed PMID: 8358388.
2: Yoshimi A, Hashizume H, Kitagawa M, Nishimura K, Kakeya N. Characteristics of 1,3-bis-(2-ethoxycarbonylchromon-5-yloxy)-2-((S)- lysyloxy)propane dihydrochloride (N-556), a prodrug for the oral delivery of disodium cromoglycate, in absorption and excretion in rats and rabbits. J Pharmacobiodyn. 1992 Dec;15(12):681-6. PubMed PMID: 1296978.
3: Nakamura S, Yamamura H, Kohno S, Ohata K, Yoshimi A, Nishimura K, Kakeya N. Effects of N-556 on experimental allergy models in rats. Arerugi. 1990 Dec;39(12):1621-8. PubMed PMID: 2096808.
4: Nagai H, Yamaguchi S, Maeda Y, Tanaka H. Role of mast cells, eosinophils and IL-5 in the development of airway hyperresponsiveness in sensitized mice. Clin Exp Allergy. 1996 Jun;26(6):642-7. PubMed PMID: 8809421.