WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H563223
CAS#: 1808260-45-8
Description: ML356 is a selective inhibitor of FAS-TE. It act as an inhibitor of the thioesterase domain of fatty acid synthase.
Hodoodo Cat#: H563223
Name: ML356
CAS#: 1808260-45-8
Chemical Formula: C19H25N3O4S2
Exact Mass: 423.13
Molecular Weight: 423.540
Elemental Analysis: C, 53.88; H, 5.95; N, 9.92; O, 15.11; S, 15.14
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Synonym: ML356; ML-356; ML 356;
IUPAC/Chemical Name: 2-Ethyl-N-[4-(4-morpholin-4-ylsulfonylphenyl)-1,3-thiazol-2-yl]butanamide
InChi Key: YKNITTNJEATJKT-UHFFFAOYSA-N
InChi Code: InChI=1S/C19H25N3O4S2/c1-3-14(4-2)18(23)21-19-20-17(13-27-19)15-5-7-16(8-6-15)28(24,25)22-9-11-26-12-10-22/h5-8,13-14H,3-4,9-12H2,1-2H3,(H,20,21,23)
SMILES Code: CCC(CC)C(NC1=NC(C2=CC=C(S(=O)(N3CCOCC3)=O)C=C2)=CS1)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 423.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Ardecky R, Hedrick MP, Gosalia P, Yamamoto F, Milewski M, Barron N, Sun Q, Zhou J, Ganji S, Mehta A, Sugarman E, Nguyen K, Vasile S, Suyama E, Teriete P, Sheffler D, Lee PS, Mattmann M, De Ingeniis J, Stonich D, Mangravita-Novo A, Salaniwal S, Kung P, Diwan J, Smith LH, Sergienko E, Chung TDY, Pinkerton AB, Cosford NDP, Smith JW. Selective inhibitors of FAS-TE. 2013 Apr 12 [updated 2014 Jan 13]. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. Available from http://www.ncbi.nlm.nih.gov/books/NBK189923/ PubMed PMID: 24624464.