WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H597555
CAS#: 90145-64-5
Description: H 189 is a decapeptide analog of human renin substrate with statine replacing leucine.
Hodoodo Cat#: H597555
Name: H 189
CAS#: 90145-64-5
Chemical Formula: C62H93N17O12
Exact Mass: 1,267.72
Molecular Weight: 1,268.530
Elemental Analysis: C, 58.70; H, 7.39; N, 18.77; O, 15.13
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Synonym: H 189; H-189; H189;
IUPAC/Chemical Name: ((3S,4S)-4-((S)-2-((S)-2-((S)-1-(L-prolyl-L-histidyl)pyrrolidine-2-carboxamido)-3-phenylpropanamido)-3-(1H-imidazol-4-yl)propanamido)-3-hydroxy-6-methylheptanoyl)-L-valyl-L-isoleucyl-L-histidyl-L-lysine
InChi Key: PZJOKAFPZVCZBJ-DJQQXEBLSA-N
InChi Code: InChI=1S/C62H93N17O12/c1-7-37(6)53(60(88)75-47(26-40-30-65-33-69-40)56(84)71-43(62(90)91)17-11-12-20-63)78-59(87)52(36(4)5)77-51(81)28-50(80)44(23-35(2)3)72-57(85)46(25-39-29-64-32-68-39)73-55(83)45(24-38-15-9-8-10-16-38)74-58(86)49-19-14-22-79(49)61(89)48(27-41-31-66-34-70-41)76-54(82)42-18-13-21-67-42/h8-10,15-16,29-37,42-50,52-53,67,80H,7,11-14,17-28,63H2,1-6H3,(H,64,68)(H,65,69)(H,66,70)(H,71,84)(H,72,85)(H,73,83)(H,74,86)(H,75,88)(H,76,82)(H,77,81)(H,78,87)(H,90,91)/t37-,42-,43-,44-,45-,46-,47-,48-,49-,50-,52-,53-/m0/s1
SMILES Code: NCCCC[C@@H](C(O)=O)NC([C@H](CC1=CNC=N1)NC([C@H]([C@@H](C)CC)NC([C@H](C(C)C)NC(C[C@H](O)[C@@H](NC([C@H](CC2=CNC=N2)NC([C@H](CC3=CC=CC=C3)NC([C@H]4N(C([C@H](CC5=CNC=N5)NC([C@H]6NCCC6)=O)=O)CCC4)=O)=O)=O)CC(C)C)=O)=O)=O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 1,268.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Tree M, Atrash B, Donovan B, Gamble J, Hallett A, Hughes M, Jones DM, Leckie B, Lever AF, Morton JJ, et al. New inhibitors of human renin tested in vitro and in vivo in the anaesthetized baboon. J Hypertens. 1983 Dec;1(4):399-403. PubMed PMID: 6398331.
2: Bailey D, Cooper JB, Veerapandian B, Blundell TL, Atrash B, Jones DM, Szelke M. X-ray-crystallographic studies of complexes of pepstatin A and a statine-containing human renin inhibitor with endothiapepsin. Biochem J. 1993 Jan 15;289 ( Pt 2):363-71. PubMed PMID: 8424781; PubMed Central PMCID: PMC1132176.
3: Gómez J, Semo N, Freire E. Structural thermodynamic study of the binding of renin inhibitors to endothiapepsin. Adv Exp Med Biol. 1998;436:325-8. PubMed PMID: 9561236.