Schradan

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H592070

CAS#: 152-16-9

Description: Schradan is a biochemical.

Chemical Structure

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Schradan
CAS# 152-16-9
Instruction

Theoretical Analysis

Hodoodo Cat#: H592070
Name: Schradan
CAS#: 152-16-9
Chemical Formula: C8H24N4O3P2
Exact Mass: 286.13
Molecular Weight: 286.250
Elemental Analysis: C, 33.57; H, 8.45; N, 19.57; O, 16.77; P, 21.64

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Schradan; NSC 8929; NSC-8929; NSC8929

IUPAC/Chemical Name: Diphosphoramide, N,N,N',N',N'',N'',N''',N'''-octamethyl-

InChi Key: SZKKRCSOSQAJDE-UHFFFAOYSA-N

InChi Code: InChI=1S/C8H24N4O3P2/c1-9(2)16(13,10(3)4)15-17(14,11(5)6)12(7)8/h1-8H3

SMILES Code: O=P(N(C)C)(OP(N(C)C)(N(C)C)=O)N(C)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 286.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Kasagami T, Miyamoto T, Yamamoto I. Activated transformations of organophosphorus insecticides in the case of non-AChE inhibitory oxons. Pest Manag Sci. 2002 Nov;58(11):1107-17. Review. PubMed PMID: 12449529.

2: EDERY H. Effects of organophosphorous compounds, oximes and atropine injected into the third ventricle of unanaesthetized dogs. Br J Pharmacol Chemother. 1962 Feb;18:19-28. PubMed PMID: 13889182; PubMed Central PMCID: PMC1482163.

3: LESSIN AW. Pharmacological methods of estimating inhibition of drug oxidation in the mouse. Br J Pharmacol Chemother. 1959 Jun;14(2):251-5. PubMed PMID: 13662584; PubMed Central PMCID: PMC1481781.

4: FENWICK ML. The production of an esterase inhibitor from schradan in the fat body of the desert locust. Biochem J. 1958 Nov;70(3):373-81. PubMed PMID: 13596353; PubMed Central PMCID: PMC1196684.

5: O'BRIEN RD, DAVISON AN. Antagonists to schradan poisoning in mice. Can J Biochem Physiol. 1958 Nov;36(11):1203-10. PubMed PMID: 13585228.

6: O'BRIEN RD, SPENCER EY. Action of schradan in the cockroach. Nature. 1957 Jan 5;179(4549):52-3. PubMed PMID: 13387754.

7: O'BRIEN RD. The mechanism of schradan activation by liver microsomes. Can J Biochem Physiol. 1957 Jan;35(1):45-54. PubMed PMID: 13396661.

8: O'BRIEN RD. Activation of schradan by mammalian tissue homogenates. Can J Biochem Physiol. 1956 Nov;34(6):1131-41. PubMed PMID: 13374578.

9: DAVISON AN. Conversion of schradan and parathion by an enzyme system of rat liver. Nature. 1954 Dec 4;174(4440):1056. PubMed PMID: 13214074.

10: BARNES JM, DENZ FA. The reaction of rats to diets containing octamethyl pyrophosphoramide (schradan) and OO-diethyl-Sethylmercaptoethanol thiophosphate (systox). Br J Ind Med. 1954 Jan;11(1):11-9. PubMed PMID: 13140812; PubMed Central PMCID: PMC1037510.

11: JONES GD, THOMAS WD. Contamination of nectar with the systemic insecticide schradan. Nature. 1953 Feb 7;171(4345):263. PubMed PMID: 13036851.

12: GARDINER JE, KILBY BA. Biochemistry of organic phosphorus insecticides. I. The mammalian metabolism of bis(dimethylamino) phosphorous anhydride (Schradan). Biochem J. 1952 Apr;51(1):78-85. PubMed PMID: 14944535; PubMed Central PMCID: PMC1197790.

13: HOFMANN-CREDNER D, SIEDEK H. Distribution and fate of schradan (bisdimethyl-aminophosphonous anhydride) in mammals, using a radioactive compound. Arch Int Pharmacodyn Ther. 1952 Feb;89(1):74-81. PubMed PMID: 14944313.