WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H597583
CAS#: 84311-50-2
Description: Nph-peptide is used for photoaffinity labeling of N-formyl peptide receptor site of intact human polymorphonuclear leukocytes.
Hodoodo Cat#: H597583
Name: Nph-peptide
CAS#: 84311-50-2
Chemical Formula: C55H78N12O12
Exact Mass: 1,098.59
Molecular Weight: 1,099.300
Elemental Analysis: C, 60.09; H, 7.15; N, 15.29; O, 17.46
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.
Synonym: Nph-peptide;
IUPAC/Chemical Name: N6-(6-((4-azido-2-nitrophenyl)amino)hexanoyl)-N2-(((S)-2-((S)-2-((S)-2-((S)-2-formamidohexanamido)-4-methylpentanamido)-3-phenylpropanamido)hexanoyl)-L-tyrosyl)-L-lysine
InChi Key: KPHWFSOLBPULFR-FQEQRRFLSA-N
InChi Code: InChI=1S/C55H78N12O12/c1-5-7-19-42(59-35-68)50(71)62-45(31-36(3)4)52(73)64-46(32-37-17-11-9-12-18-37)53(74)60-43(20-8-6-2)51(72)63-47(33-38-23-26-40(69)27-24-38)54(75)61-44(55(76)77)21-14-16-30-58-49(70)22-13-10-15-29-57-41-28-25-39(65-66-56)34-48(41)67(78)79/h9,11-12,17-18,23-28,34-36,42-47,57,69H,5-8,10,13-16,19-22,29-33H2,1-4H3,(H,58,70)(H,59,68)(H,60,74)(H,61,75)(H,62,71)(H,63,72)(H,64,73)(H,76,77)/t42-,43-,44-,45-,46-,47-/m0/s1
SMILES Code: O=C(O)[C@H](CCCCNC(CCCCCNC1=CC=C(N=[N+]=[N-])C=C1[N+]([O-])=O)=O)NC([C@H](CC2=CC=C(O)C=C2)NC([C@H](CCCC)NC([C@H](CC3=CC=CC=C3)NC([C@H](CC(C)C)NC([C@H](CCCC)NC=O)=O)=O)=O)=O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 1,099.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Dolmatch B, Niedel J. Formyl peptide chemotactic receptor. Evidence for an active proteolytic fragment. J Biol Chem. 1983 Jun 25;258(12):7570-7. PubMed PMID: 6305946.
2: Allen RA, Jesaitis AJ, Sklar LA, Cochrane CG, Painter RG. Physicochemical properties of the N-formyl peptide receptor on human neutrophils. J Biol Chem. 1986 Feb 5;261(4):1854-7. PubMed PMID: 3944114.
3: Allen RA, Jesaitis AJ, Cochrane CG. Photoaffinity labelling of N-formyl peptide receptors. Pharmacol Ther. 1987;33(2-3):333-48. Review. PubMed PMID: 3310037.
4: Schmitt M, Painter RG, Jesaitis AJ, Preissner K, Sklar LA, Cochrane CG. Photoaffinity labeling of the N-formyl peptide receptor binding site of intact human polymorphonuclear leukocytes. A label suitable for following the fate of the receptor-ligand complex. J Biol Chem. 1983 Jan 10;258(1):649-54. PubMed PMID: 6294117.