WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H563243
CAS#: 761401-89-2
Description: DANP is a bulge base recognition probe. It is a strong and specific ligand of the single cytosine and thymine bulges with exclusively 1:1 stoichiometry..
Hodoodo Cat#: H563243
Name: DANP
CAS#: 761401-89-2
Chemical Formula: C14H22N6
Exact Mass: 274.19
Molecular Weight: 274.370
Elemental Analysis: C, 61.29; H, 8.08; N, 30.63
This product is not in stock, which may be available by custom synthesis.
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Synonym: DANP;
IUPAC/Chemical Name: N,N'-Bis(3-aminopropyl)-2,7-diamino-1,8-naphthyridine
InChi Key: NKZWHPWGLZLGMH-UHFFFAOYSA-N
InChi Code: InChI=1S/C14H22N6/c15-7-1-9-17-12-5-3-11-4-6-13(18-10-2-8-16)20-14(11)19-12/h3-6H,1-2,7-10,15-16H2,(H2,17,18,19,20)
SMILES Code: NCCCNC1=NC2=NC(NCCCN)=CC=C2C=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 274.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
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3: Xiong L, Teng CL, Zhu BW, Tzeng GH, Huang SL. Using the D-DANP-mV Model to Explore the Continuous System Improvement Strategy for Sustainable Development of Creative Communities. Int J Environ Res Public Health. 2017 Oct 27;14(11). pii: E1309. doi: 10.3390/ijerph14111309. PubMed PMID: 29076994; PubMed Central PMCID: PMC5707948.
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6: Chen HM, Wu CH, Tsai SB, Yu J, Wang J, Zheng Y. Exploring key factors in online shopping with a hybrid model. Springerplus. 2016 Nov 30;5(1):2046. doi: 10.1186/s40064-016-3746-4. eCollection 2016. PubMed PMID: 27995023; PubMed Central PMCID: PMC5130971.
7: Murata A, Otabe T, Zhang J, Nakatani K. BzDANP, a Small-Molecule Modulator of Pre-miR-29a Maturation by Dicer. ACS Chem Biol. 2016 Oct 21;11(10):2790-2796. Epub 2016 Aug 25. PubMed PMID: 27536863.
8: Chen H, Parimelalagan M, Takei F, Hapuarachchi HC, Koay ES, Ng LC, Ho PS, Nakatani K, Chu JJ. Development of 2, 7-Diamino-1, 8-Naphthyridine (DANP) Anchored Hairpin Primers for RT-PCR Detection of Chikungunya Virus Infection. PLoS Negl Trop Dis. 2016 Aug 29;10(8):e0004887. doi: 10.1371/journal.pntd.0004887. eCollection 2016 Aug. PubMed PMID: 27571201; PubMed Central PMCID: PMC5003370.
9: Kumar Verma R, Takei F, Nakatani K. Synthesis and Photophysical Properties of Fluorescence Molecular Probe for Turn-ON-Type Detection of Cytosine Bulge DNA. Org Lett. 2016 Jul 1;18(13):3170-3. doi: 10.1021/acs.orglett.6b01378. Epub 2016 Jun 14. PubMed PMID: 27300443.
10: Jin G, Jin M, Jin Z, Gao Z, Yin X. Docetaxel-loaded PEG-albumin nanoparticles with improved antitumor efficiency against non-small cell lung cancer. Oncol Rep. 2016 Aug;36(2):871-6. doi: 10.3892/or.2016.4863. Epub 2016 Jun 8. PubMed PMID: 27279008.
11: Peng L, Jiang D, Wang Z, Hua L, Li H. Dopant-assisted negative photoionization Ion mobility spectrometry coupled with on-line cooling inlet for real-time monitoring H2S concentration in sewer gas. Talanta. 2016 Jun 1;153:295-300. doi: 10.1016/j.talanta.2016.03.041. Epub 2016 Mar 12. PubMed PMID: 27130121.
12: Wu L, Xu G, Wang X. Identifying critical factors influencing the disposal of dead pigs by farmers in China. Environ Sci Pollut Res Int. 2016 Jan;23(1):661-72. doi: 10.1007/s11356-015-5284-y. Epub 2015 Sep 2. PubMed PMID: 26330314.
13: Cheng S, Wang W, Zhou Q, Chen C, Peng L, Hua L, Li Y, Hou K, Li H. Fast Switching of CO3(-)(H2O)n and O2(-)(H2O)n reactant ions in dopant-assisted negative photoionization ion mobility spectrometry for explosives detection. Anal Chem. 2014 Mar 4;86(5):2687-93. doi: 10.1021/ac404067z. Epub 2014 Feb 11. PubMed PMID: 24484058.
14: Yang J, Wang F, Zhang J, Wang G, Gong X. A theoretical study on 1,5-diazido-3-nitrazapentane (DANP) and 1,7-diazido-2,4,6-trinitrazaheptane (DATNH): molecular and crystal structures, thermodynamic and detonation properties, and pyrolysis mechanism. J Mol Model. 2013 Dec;19(12):5367-76. doi: 10.1007/s00894-013-2014-6. Epub 2013 Oct 27. PubMed PMID: 24162066.
15: Chen H, Takei F, Koay ES, Nakatani K, Chu JJ. A novel DANP-coupled hairpin RT-PCR for rapid detection of Chikungunya virus. J Mol Diagn. 2013 Mar;15(2):227-33. doi: 10.1016/j.jmoldx.2012.10.004. Epub 2013 Jan 9. PubMed PMID: 23313361.
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17: Piacquadio D, Smith S, Anderson R. A comparison of commercially available polymethylmethacrylate-based soft tissue fillers. Dermatol Surg. 2008 Jun;34 Suppl 1:S48-52. doi: 10.1111/j.1524-4725.2008.34242.x. PubMed PMID: 18547181.
18: Kobori A, Mori T, Yamayoshi A, Murakami A. Synthesis of naphthyridine-conjugated DNA probes and their application to SNPs typing. Nucleic Acids Symp Ser (Oxf). 2007;(51):309-10. PubMed PMID: 18029710.
19: Zhang J, Takei F, Nakatani K. Emission of characteristic fluorescence from the ligand-cytosine complex in U_A/ACU bulged RNA duplex. Bioorg Med Chem. 2007 Jul 15;15(14):4813-7. Epub 2007 May 6. PubMed PMID: 17513115.
20: Takei F, Suda H, Hagihara M, Zhang J, Kobori A, Nakatani K. Allele specific C-bulge probes with one unique fluorescent molecule discriminate the single nucleotide polymorphism in DNA. Chemistry. 2007;13(16):4452-7. PubMed PMID: 17352435.
