SMART-F

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H592080

CAS#: 1135798-02-5

Description: SMART-F is a biochemical.


Chemical Structure

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SMART-F
CAS# 1135798-02-5

Theoretical Analysis

Hodoodo Cat#: H592080
Name: SMART-F
CAS#: 1135798-02-5
Chemical Formula: C19H16NO4S
Exact Mass: 373.08
Molecular Weight: 373.400
Elemental Analysis: C, 61.12; H, 4.32; F, 5.09; N, 3.75; O, 17.14; S, 8.59

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: SMART-F

IUPAC/Chemical Name: [2-(4-Fluorophenyl)-thiazol-4-yl]-(3,4,5-trimethoxyphenyl)-methanone

InChi Key: LNESSNOGBADQPV-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H16FNO4S/c1-23-15-8-12(9-16(24-2)18(15)25-3)17(22)14-10-26-19(21-14)11-4-6-13(20)7-5-11/h4-10H,1-3H3

SMILES Code: O=C(C1=CSC(C2=CC=C(F)C=C2)=N1)C3=CC(OC)=C(OC)C(OC)=C3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 373.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Hanna EB, Smart FW, Hanna Deschamps E. Mechanisms of Discrepancy Between Pulmonary Artery Wedge Pressure and Left Ventricular End-Diastolic Pressure in Heart Failure With Preserved Ejection Fraction. JACC Heart Fail. 2018 Mar;6(3):267-269. doi: 10.1016/j.jchf.2017.11.009. PubMed PMID: 29496029.

2: Polhemus DJ, Trivedi RK, Gao J, Li Z, Scarborough AL, Goodchild TT, Varner KJ, Xia H, Smart FW, Kapusta DR, Lefer DJ. Renal Sympathetic Denervation Protects the Failing Heart Via Inhibition of Neprilysin Activity in the Kidney. J Am Coll Cardiol. 2017 Oct 24;70(17):2139-2153. doi: 10.1016/j.jacc.2017.08.056. PubMed PMID: 29050562.

3: Gao J, Kerut EK, Smart F, Katsurada A, Seth D, Navar LG, Kapusta DR. Sympathoinhibitory Effect of Radiofrequency Renal Denervation in Spontaneously Hypertensive Rats With Established Hypertension. Am J Hypertens. 2016 Dec 1;29(12):1394-1401. doi: 10.1093/ajh/hpw089. PubMed PMID: 27538721.

4: Polhemus DJ, Gao J, Scarborough AL, Trivedi R, McDonough KH, Goodchild TT, Smart F, Kapusta DR, Lefer DJ. Radiofrequency Renal Denervation Protects the Ischemic Heart via Inhibition of GRK2 and Increased Nitric Oxide Signaling. Circ Res. 2016 Jul 22;119(3):470-80. doi: 10.1161/CIRCRESAHA.115.308278. Epub 2016 Jun 13. PubMed PMID: 27296507; PubMed Central PMCID: PMC4959827.

5: Gheorghiade M, Greene SJ, Butler J, Filippatos G, Lam CS, Maggioni AP, Ponikowski P, Shah SJ, Solomon SD, Kraigher-Krainer E, Samano ET, Müller K, Roessig L, Pieske B; SOCRATES-REDUCED Investigators and Coordinators. Effect of Vericiguat, a Soluble Guanylate Cyclase Stimulator, on Natriuretic Peptide Levels in Patients With Worsening Chronic Heart Failure and Reduced Ejection Fraction: The SOCRATES-REDUCED Randomized Trial. JAMA. 2015 Dec 1;314(21):2251-62. doi: 10.1001/jama.2015.15734. PubMed PMID: 26547357.

6: Hanna EB, Smart FW. Letter by Hanna and Smart Regarding Article, "Clinical Diagnosis of Pulmonary Hypertension". Circulation. 2015 Sep 1;132(9):e133. doi: 10.1161/CIRCULATIONAHA.114.014308. PubMed PMID: 26324670.

7: Galiè N, Barberà JA, Frost AE, Ghofrani HA, Hoeper MM, McLaughlin VV, Peacock AJ, Simonneau G, Vachiery JL, Grünig E, Oudiz RJ, Vonk-Noordegraaf A, White RJ, Blair C, Gillies H, Miller KL, Harris JH, Langley J, Rubin LJ; AMBITION Investigators. Initial Use of Ambrisentan plus Tadalafil in Pulmonary Arterial Hypertension. N Engl J Med. 2015 Aug 27;373(9):834-44. doi: 10.1056/NEJMoa1413687. PubMed PMID: 26308684.

8: Pieske B, Butler J, Filippatos G, Lam C, Maggioni AP, Ponikowski P, Shah S, Solomon S, Kraigher-Krainer E, Samano ET, Scalise AV, Müller K, Roessig L, Gheorghiade M; SOCRATES Investigators and Coordinators. Rationale and design of the SOluble guanylate Cyclase stimulatoR in heArT failurE Studies (SOCRATES). Eur J Heart Fail. 2014 Sep;16(9):1026-38. doi: 10.1002/ejhf.135. Epub 2014 Jul 24. PubMed PMID: 25056511.

9: Amir O, Barak-Shinar D, Henry A, Smart FW. Photoplethysmography as a single source for analysis of sleep-disordered breathing in patients with severe cardiovascular disease. J Sleep Res. 2012 Feb;21(1):94-100. doi: 10.1111/j.1365-2869.2011.00927.x. Epub 2011 Jun 14. PubMed PMID: 21672069.

10: Amir O, Barak-Shinar D, Wolff R, Paz H, Dori G, Smart FW, Lewis BS. Long-term assessment of nocturnal Cheyne-Stokes respiration in patients with heart failure. Sleep Breath. 2011 Dec;15(4):855-60. doi: 10.1007/s11325-010-0450-4. Epub 2010 Dec 2. PubMed PMID: 21125426.

11: Li CM, Wang Z, Lu Y, Ahn S, Narayanan R, Kearbey JD, Parke DN, Li W, Miller DD, Dalton JT. Biological activity of 4-substituted methoxybenzoyl-aryl-thiazole: an active microtubule inhibitor. Cancer Res. 2011 Jan 1;71(1):216-24. doi: 10.1158/0008-5472.CAN-10-1725. Epub 2010 Nov 16. PubMed PMID: 21084278; PubMed Central PMCID: PMC3039446.

12: Slaughter MS, Rogers JG, Milano CA, Russell SD, Conte JV, Feldman D, Sun B, Tatooles AJ, Delgado RM 3rd, Long JW, Wozniak TC, Ghumman W, Farrar DJ, Frazier OH; HeartMate II Investigators. Advanced heart failure treated with continuous-flow left ventricular assist device. N Engl J Med. 2009 Dec 3;361(23):2241-51. doi: 10.1056/NEJMoa0909938. Epub 2009 Nov 17. PubMed PMID: 19920051.

13: Amir O, Delgado RM 3rd, Kar B, Smart FW. The value of cardiac magnetic resonance imaging in the diagnosis of isolated non-compaction of the left ventricle. Isr Med Assoc J. 2009 May;11(5):313-4. PubMed PMID: 19637513.

14: Zile MR, Bourge RC, Bennett TD, Stevenson LW, Cho YK, Adamson PB, Aaron MF, Aranda JM Jr, Abraham WT, Smart FW, Kueffer FJ. Application of implantable hemodynamic monitoring in the management of patients with diastolic heart failure: a subgroup analysis of the COMPASS-HF trial. J Card Fail. 2008 Dec;14(10):816-23. doi: 10.1016/j.cardfail.2008.07.235. Epub 2008 Sep 6. PubMed PMID: 19041044.

15: Zile MR, Bennett TD, St John Sutton M, Cho YK, Adamson PB, Aaron MF, Aranda JM Jr, Abraham WT, Smart FW, Stevenson LW, Kueffer FJ, Bourge RC. Transition from chronic compensated to acute decompensated heart failure: pathophysiological insights obtained from continuous monitoring of intracardiac pressures. Circulation. 2008 Sep 30;118(14):1433-41. doi: 10.1161/CIRCULATIONAHA.108.783910. Epub 2008 Sep 15. PubMed PMID: 18794390.

16: Bourge RC, Abraham WT, Adamson PB, Aaron MF, Aranda JM Jr, Magalski A, Zile MR, Smith AL, Smart FW, O'Shaughnessy MA, Jessup ML, Sparks B, Naftel DL, Stevenson LW; COMPASS-HF Study Group. Randomized controlled trial of an implantable continuous hemodynamic monitor in patients with advanced heart failure: the COMPASS-HF study. J Am Coll Cardiol. 2008 Mar 18;51(11):1073-9. doi: 10.1016/j.jacc.2007.10.061. PubMed PMID: 18342224.

17: Smart F, Aschrafi A, Atkins A, Owens GC, Pilotte J, Cunningham BA, Vanderklish PW. Two isoforms of the cold-inducible mRNA-binding protein RBM3 localize to dendrites and promote translation. J Neurochem. 2007 Jun;101(5):1367-79. Epub 2007 Mar 30. PubMed PMID: 17403028.

18: Voelkel NF, Quaife RA, Leinwand LA, Barst RJ, McGoon MD, Meldrum DR, Dupuis J, Long CS, Rubin LJ, Smart FW, Suzuki YJ, Gladwin M, Denholm EM, Gail DB; National Heart, Lung, and Blood Institute Working Group on Cellular and Molecular Mechanisms of Right Heart Failure. Right ventricular function and failure: report of a National Heart, Lung, and Blood Institute working group on cellular and molecular mechanisms of right heart failure. Circulation. 2006 Oct 24;114(17):1883-91. PubMed PMID: 17060398.

19: Packer M, Abraham WT, Mehra MR, Yancy CW, Lawless CE, Mitchell JE, Smart FW, Bijou R, O'Connor CM, Massie BM, Pina IL, Greenberg BH, Young JB, Fishbein DP, Hauptman PJ, Bourge RC, Strobeck JE, Murali S, Schocken D, Teerlink JR, Levy WC, Trupp RJ, Silver MA; Prospective Evaluation and Identification of Cardiac Decompensation by ICG Test (PREDICT) Study Investigators and Coordinators. Utility of impedance cardiography for the identification of short-term risk of clinical decompensation in stable patients with chronic heart failure. J Am Coll Cardiol. 2006 Jun 6;47(11):2245-52. Epub 2006 May 15. PubMed PMID: 16750691.

20: Palanichamy N, Gregoric ID, La Francesca S, Smart FW. Mycotic pseudo-aneurysm of the ascending thoracic aorta after cardiac transplantation. J Heart Lung Transplant. 2006 Jun;25(6):730-3. Epub 2006 May 2. PubMed PMID: 16730580.