WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H597625
CAS#: 61370-88-5
Description: Enkephalin-met, des-tyr(1)- ccauses retrograde amnesia in rats.
Hodoodo Cat#: H597625
Name: Enkephalin-met, des-tyr(1)-
CAS#: 61370-88-5
Chemical Formula: C18H26N4O5S
Exact Mass: 410.16
Molecular Weight: 410.480
Elemental Analysis: Chemical Formula: Exact Mass: Molecular Weight: Elemental Analysis: C, 52.67; H, 6.38; N, 13.65; O, 19.49; S, 7.81
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Synonym: Enkephalin-met, des-tyr(1)-; 1-De-tyr-met-enkephalin; Met-enkephalin, des-tyr(1);
IUPAC/Chemical Name: glycylglycyl-L-phenylalanyl-L-methionine
InChi Key: KWHAJHJQOWBJEG-KBPBESRZSA-N
InChi Code: InChI=1S/C18H26N4O5S/c1-28-8-7-13(18(26)27)22-17(25)14(9-12-5-3-2-4-6-12)21-16(24)11-20-15(23)10-19/h2-6,13-14H,7-11,19H2,1H3,(H,20,23)(H,21,24)(H,22,25)(H,26,27)/t13-,14-/m0/s1
SMILES Code: CSCC[C@@H](C(O)=O)NC([C@H](CC1=CC=CC=C1)NC(CNC(CN)=O)=O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 410.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Kowalski J. Immunologic action of [Met5]enkephalin fragments. Eur J Pharmacol. 1998 Apr 17;347(1):95-9. PubMed PMID: 9650853.
2: Carrasco MA, Dias RD, Perry ML, Wofchuk ST, Souza DO, Izquierdo I. Effect of morphine, ACTH, epinephrine, Met-, Leu- and des-Tyr-Met-enkephalin on beta-endorphin-like immunoreactivity of rat brain. Psychoneuroendocrinology. 1982;7(2-3):229-34. PubMed PMID: 6294717.
3: Izquierdo I, Dias RD. Retrograde amnesia caused by Met-, Leu- and des-Try-Met-enkephalin in the rat and its reversal by naloxone. Neurosci Lett. 1981 Mar 10;22(2):189-93. PubMed PMID: 7194992.
4: Neidle A, Kelly JA. The isolation of a peptidyl dipeptidase from mouse brain cytosol that cleaves adrenocorticotropic hormone-(7-10) and des-tyrosine-enkephalins. Arch Biochem Biophys. 1984 Aug 15;233(1):115-26. PubMed PMID: 6087738.
5: Hsueh CM, Hiramoto RN, Ghanta VK. The central effect of methionine-enkephalin on NK cell activity. Brain Res. 1992 Apr 24;578(1-2):142-8. PubMed PMID: 1511272.
6: Janković BD, Veljić J, Pesić G, Marić D. Enkephalinase-inhibitors modulate immune responses. Int J Neurosci. 1991 Jul;59(1-3):45-51. PubMed PMID: 1774139.
7: Camlica Y, Aşkin A, Cömelekoğlu U. Evidence for the involvement of an opioid system in sciatic nerve of Rana ridibunda. Neuropeptides. 2004 Apr-Jun;38(2-3):83-91. PubMed PMID: 15223270.
8: Dias RD, Carrasco MA, Izquierdo I. Effect of the pre-training administration of beta-endorphin, leucine-, methionine- and [des-Tyr1] methionine-enkephalin on the acquisition and retention of a shuttle avoidance response by rats. Braz J Med Biol Res. 1982 Apr;15(1):55-60. PubMed PMID: 6891276.
9: Izquierdo I, Dias RD, Souza DO, Carrasco MA, Elisabetsky E, Perry ML. The role of opioid peptides in memory and learning. Behav Brain Res. 1980 Dec;1(6):451-68. Review. PubMed PMID: 6266433.
