WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H597740
CAS#: 103494-23-1
Description: U 67827E is a long-lasting cholecystokinin agonist U 67827E decreases food intake.
Hodoodo Cat#: H597740
Name: U 67827E
CAS#: 103494-23-1
Chemical Formula: C53H68N10O17S
Exact Mass: 1,148.45
Molecular Weight: 1,149.240
Elemental Analysis: C, 55.39; H, 5.96; N, 12.19; O, 23.67; S, 2.79
This product is not in stock, which may be available by custom synthesis.
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Synonym: U 67827E; U-67827E; U67827E; N-Ac-Asp-tyr(So3H)-nle-gly-trp-nle-asp-phe-NH2;
IUPAC/Chemical Name: (3S,6S,9S,15S,18S,21S)-9-((1H-indol-3-yl)methyl)-19-acetyl-21-amino-3-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)carbamoyl)-6,15-dibutyl-5,8,11,14,17,20-hexaoxo-18-(4-(sulfooxy)benzyl)-4,7,10,13,16,19-hexaazatricosanedioic acid
InChi Key: FXRJJLGINFLBGK-TZLMNZOISA-N
InChi Code: InChI=1S/C53H68N10O17S/c1-4-6-16-38(60-52(75)43(63(30(3)64)53(76)36(54)26-45(66)67)24-32-19-21-34(22-20-32)80-81(77,78)79)48(71)57-29-44(65)58-41(25-33-28-56-37-18-12-11-15-35(33)37)50(73)59-39(17-7-5-2)49(72)62-42(27-46(68)69)51(74)61-40(47(55)70)23-31-13-9-8-10-14-31/h8-15,18-22,28,36,38-43,56H,4-7,16-17,23-27,29,54H2,1-3H3,(H2,55,70)(H,57,71)(H,58,65)(H,59,73)(H,60,75)(H,61,74)(H,62,72)(H,66,67)(H,68,69)(H,77,78,79)/t36-,38-,39-,40-,41-,42-,43-/m0/s1
SMILES Code: O=C(N)[C@H](CC1=CC=CC=C1)NC([C@H](CC(O)=O)NC([C@H](CCCC)NC([C@H](CC2=CNC3=C2C=CC=C3)NC(CNC([C@H](CCCC)NC([C@H](CC4=CC=C(OS(=O)(O)=O)C=C4)N(C([C@H](CC(O)=O)N)=O)C(C)=O)=O)=O)=O)=O)=O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 1,149.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Moran TH, Sawyer TK, Seeb DH, Ameglio PJ, Lombard MA, McHugh PR. Potent and sustained satiety actions of a cholecystokinin octapeptide analogue. Am J Clin Nutr. 1992 Jan;55(1 Suppl):286S-290S. doi: 10.1093/ajcn/55.1.286s. PubMed PMID: 1728841.
2: Foltin RW, Moran TH. Food intake in baboons: effects of a long-acting cholecystokinin analog. Appetite. 1989 Apr;12(2):145-52. PubMed PMID: 2764555.
3: Schwartz GJ, Netterville LA, McHugh PR, Moran TH. Gastric loads potentiate inhibition of food intake produced by a cholecystokinin analogue. Am J Physiol. 1991 Nov;261(5 Pt 2):R1141-6. PubMed PMID: 1951762.
